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Bioinformatics News 12/2009 (Page 13)

How Algal Biofuels Lost a Decade in the Race to Replace Oil (Wired News)
Biofuels made from algae are touted as a solution to help end the age of oil. But halting a program to develop the tech in the 1990s may have set back making diesel from pond scum for years. As the program languished, the living archive of valuable genetic material scientists had collected was largely lost.

Former AP Biotech Exec Joins Aclara as Senior VP of R&D (GenomeWeb News)
NEW YORK, April 25 – Dennis Harris, formerly Amersham Pharmacia Biotech’s North American vice president of research & development, has taken a newly created position as senior vice president of R&D at microfluidics-maker Aclara Biosciences, Aclara said Wednesday.

Merck s Maturing Proteomics Platform Helps Drive the Pharma s Molecular Profiling Effort (GenomeWeb News)
Like most large pharmaceutical companies, Merck invested heavily in gene expression profiling before paying much notice to proteomics.

How Algal Biofuels Lost a Decade in the Race to Replace Oil (MalaysiaNews.net)
Aquatic Species Program (.pdf), initiated under President Jimmy Carter, laid the scientific foundation for making diesel-like fuel from the fat that microscopic algae accumulate in their cells. Fifty-...

Gene mutation that decreases flesh-eating disease discovered by scientists (News-Medical-Net)
Scientists at The Methodist Hospital Research Institute in Houston recently discovered a simple gene mutation that decreases the chance people will get a flesh-eating disease called necrotizing fasciitis. Further, they proved that inactivating this section of the gene lessens the devastating disease in humans.

Shell, Exxon Boost Investment in Biofuels Development, WSJ Says (Bloomberg)
Dec. 30 (Bloomberg) -- Royal Dutch Shell Plc has spent about $60 million this year to finance research at biofuels developer Codexis Inc., almost twice the amount last year, the Wall Street Journal reported, citing regulatory filings.

A Novel Gene Found For Childhood-Onset Asthma (Medical News Today)
Pediatric researchers have identified a novel gene involved in childhood asthma, in one of the largest gene studies to date of the common respiratory disease. Because the gene, called DENND1B, affects cells and signaling molecules thought to be instrumental in the immune system overreaction that occurs in asthma, the discovery may have singled out an important target for new treatments. A ...

The Return of the Algae (GenomeWeb News)
Algal biofuel researchers have lost a decade's worth of work , says this post at Wired Science.

This Week in Genome Biology (GenomeWeb News)
In Genome Biology online this week, an American team used genotyping — along with statistical and computational approaches — to look at African ancestry admixture patterns in 230 African Americans from the Human Genome Diversity Panel or participating in the ADVANCE study and 38 European Americans from ADVANCE. The researchers reported that African Americans had admixed African ancestry — mainly ...

Cracking Down on Devices (GenomeWeb News)
Two studies, released yesterday in the Journal of the American Medical Association and The American Journal of Therapeutics , looked at the quality of clinical trials submitted by cardiovascular device-makers to the Food and Drug Administration between 2000 and 2007. The JAMA study, done by University of California, San Francisco researchers, concludes that the studies " lack adequate strength ...

Back in Court (GenomeWeb News)
The California Science Center is being sued for its cancellation of a film screening , reports the Los Angeles Times . The suit, brought by the American Freedom Alliance, argues that the center violated both the First Amendment and a contract to rent the center's IMAX theater when the showing of the anti-evolution, intelligent design documentary "Darwin's Dilemma: The Mystery of the Cambrian ...

Soil Bacteria Proteins Could aid Cellulosic Ethanol (DTN / The Progressive Farmer)
Researchers at Newcastle, U.K.-based Northumbria University are collaborating with Nonlinear Dynamics Ltd. on a three-year project to use a variety of technologies to help isolate proteins in soil bacteria that could help in cellulosic ethanol production, according to Ethanol Producer Magazine.

Shell, Other oil Firms Bolster Biofuels Spending (DTN / The Progressive Farmer)
Major oil companies continue to pour money into biofuels projects, according to the Wall Street Journal.

Applied Proteomics, ALS TDI Collaborating on Markers (GenomeWeb News)
NEW YORK (GenomeWeb News) – Applied Proteomics and The ALS Therapy Development Institute (ALS TDI) are collaborating to validate protein biomarkers for tracking the progression of, and developing therapies for, amyotrophic lateral sclerosis, also called Lou Gehrig's disease.

Columbia U Spinout Therasis IDs Genes Behind Brain Cancer Aggressiveness (GenomeWeb News)
NEW YORK (GenomeWeb News) – Scientists from drug-discovery company Therasis and Columbia University have identified a pair of genes that, when simultaneously activated, cause the most lethal form of glioblastoma.

Shell, Other Oil Firms Bolster Biofuels Spending (DTN / The Progressive Farmer)
Major oil companies continue to pour money into biofuels projects, according to the Wall Street Journal. Royal Dutch Shell PLC has nearly doubled its financial support for biofuels start-up Codexis Inc.

How Algal Biofuels Lost a Decade in the Race to Replace Oil (Wired News)
Biofuels made from algae are touted as a solution to help end the age of oil. But halting a program to develop the tech in the 1990s may have set back making diesel from pond scum for years. As the program languished, the living archive of valuable genetic material scientists had collected was largely lost.

Mutant gene lessens devastation of flesh-eating bacteria (PhysOrg)
(PhysOrg.com) -- Scientists at The Methodist Hospital Research Institute in Houston recently discovered a simple gene mutation that decreases the chance people will get a flesh-eating disease called necrotizing fasciitis. Further, they proved that inactivating this section of the gene lessens the devastating disease in humans.

A useful guide for the bioinformatics tool builders [Discovering Biology in a Digital World] (ScienceBlogs)
I often get questions about bioinformatics, bioinformatics jobs and career paths. Most of the questions reflect a general sense of confusion between creating bioinformatics resources and using them. Bioinformatics is unique in this sense. No one confuses writing a package like Photoshop with being a photographer, yet for some odd reason, people seem to expect this of biologists. In the same ...

People In The News (GenomeWeb News)
NEW YORK (GenomeWeb News) – Axel Nielsen , COO of Decode Genetics, has resigned from the company, effective Jan. 1, 2010. The firm disclosed the resignation in a US Securities and Exchange Commission filing this week, but it did not say whether it intends to search for a replacement.

Venture Capital Investment in Green Technologies Approaches $5B in 2009 (Marketwire via Yahoo! Finance)
CAMBRIDGE, MA--(Marketwire - 12/30/09) - Greentech Media Inc., the industry-leading online media company covering green technology news and analysis, released year-end venture capital figures showing that VC investment in green technologies totaled $4.85 billion in 356 deals in 2009. Although the dollar total is down from 2008's $7.6 billion, the number of deals exceeded last year's total as ...

Venture Capital Investment in Green Technologies Approaches $5B in 2009 (Marketwire)
Greentech Media Reports 356 Deals Made This Year and a Boost in IPO and M&A Activity, Signaling a Continued Confidence in the Greentech Investment Sector

Discovery of new function of prion protein improves understanding of epilepsy (Science Daily)
Cellular prion protein (PrPc) plays an essential role in maintaining neurotransmitter homeostasis in the central nervous system. This discovery has been made possible by the observation that both a deficiency and an excess of the protein have a considerable effect on this homeostasis. Surprisingly, in both cases, the central nervous excitability threshold is altered to such an extent that an ...

Isis Pharmaceuticals Inc. (ISIS) Director, COO B Lynne Parshall sells 8,000 Shares (Guru Focus)
By insider. Director, COO of Isis Pharmaceuticals Inc. ( ISIS ) B Lynne Parshall sells 8,000 shares of ISIS on 12/30/2009 at an average price of $11.09 a share. Read more » »

Isis Pharmaceuticals Inc. (ISIS) Chairman, President, CEO Stanley T Crooke sells 6,535 Shares (Guru Focus)
By insider. Chairman, President, CEO of Isis Pharmaceuticals Inc. ( ISIS ) Stanley T Crooke sells 6,535 shares of ISIS on 12/30/2009 at an average price of $11.07 a share. Read more » »

Vertex, Cytoplex, Rigel, Clontech, Takara, and PerkinElmer Among Recent US Patent Winners (GenomeWeb News)
Vertex Pharmaceuticals has been awarded US Patent No. 6,969,449 , "Multi-well plate and electrode assemblies for ion channel assays."

Rolf Apweiler, Mathew Hahn, Scott Kahn, Jeff Augen, David Evans, and more (GenomeWeb News)
The Human Proteome Organization has elected Rolf Apweiler of the European Bioinformatics Institute as its next president. Apweiler is currently chair of HUPO's Proteomics Standards Initiative and leads the sequence database group at EBI, where he heads the UniProt/SwissProt database.

The top books of the year (The Norman Transcript)
Ask a roomful of people to name their favorite book of this or any year and you are likely to get a roomful of answers. We polled some of our regular book critics and staffers to compile this list of the top books of the year.

VC Investment in Greentech Approaches $5B in 2009 (GreenBiz)
Cambridge, MA — VC investment in green technologies totaled $4.85 billion in 356 deals in 2009, down from 2008's $7.6 billion, though the number of deals in 2009 exceeded the previous year, as entrepreneurs and venture firms look to greentech to help lead the economy back to health.

Tools to analyze gene expression [Gene Expression] (ScienceBlogs)
Disease Gene Characterization through Large-Scale Co-Expression Analysis : Celsius, the largest co-normalized microarray dataset of Affymetrix based gene expression, was used to calculate the correlation between all possible gene pairs on all platforms, and generate stored indexes in a web searchable format. The size of Celsius makes UGET a powerful gene characterization tool. Using a small seed ...

Genomic Toggle Switches Divide Autoimmune Diseases Into Distinct Clusters, Stanford Study Shows (Medical News Today)
Genomic switches can predispose an individual to one set of autoimmune disorders but protect the same person against another set of them, scientists at Stanford University School of Medicine have found. "Maybe we should stop considering all autoimmune diseases in one lumped category," said Atul Butte, MD, PhD, assistant professor of pediatrics and of biomedical informatics and director of the ...

8 Elected As AAAS Fellows (Medical News Today)
Eight UC Davis faculty members are among 531 new fellows elected to the American Association for the Advancement of Science this year for their efforts to advance science or its applications. The new fellows will be presented with a certificate and rosette pin on Saturday, Feb. 20, during the society's annual meeting in San Diego. Here are the new AAAS fellows from UC Davis: Professor David G ...

Genetic Causes Identified For Disturbances In Lipid Metabolism (Medical News Today)
Scientists of Helmholtz Zentrum Munchen led by Professor Karsten Suhre have identified new gene variants associated with disturbances in the lipid metabolism. Some of these common human gene variants are already known to be risk factors for diabetes mellitus. The pathomechanisms of diabetes have intrigued physicians and been the subject of much debate for many decades. These new research results ...

Mutant Gene Lessens Devastation Of Flesh Eating Bacteria (Medical News Today)
Scientists at The Methodist Hospital Research Institute in Houston recently discovered a simple gene mutation that decreases the chance people will get a flesh-eating disease called necrotizing fasciitis. Further, they proved that inactivating this section of the gene lessens the devastating disease in humans. Results of this research, funded by the National Institutes of Health and the American ...

Top 10 Medical Events Of The Decade (HuffingtonPost.com via Yahoo! News)
Read Dr. Dean Ornish's other articles on HuffingtonPost.com

Queensborough College gains major research partner (YourNabe.com)
Bayside’s Queensborough Community College has become the first community college in the nation to be selected by the Howard Hughes Medical Institute as an associate member of its Science Education Alliance research initiative.

Dr. Dean Ornish: Top 10 Medical Events Of The Decade (The Huffington Post)
In writing about the top 10 medical events of the decade, I first began writing about the latest high-tech breakthroughs in genomics, stem cell research, angiogenesis, and so on.

The Tool-Builders (GenomeWeb News)
Sandra Porter draws the distinction between bioinformaticists or bioinformatics programmers and people who use the tools the others create . "The tool builders are the programmers, architects, computational biologists, and computer scientists who write new algorithms, create databases, and build software systems.

People in the News (GenomeWeb News)
Rosetta Genomics has added two new directors to its board. The second, Kenneth Berlin , was recently named Rosetta's president and CEO. The Haynes lab studies fundamental and applied problems in immunology, nanoscience, and environmental science using a diverse set of techniques.

Mutant gene lessens devastation of flesh-eating bacteria (Science Daily)
Scientists recently discovered a simple gene mutation that decreases the chance people will get a flesh-eating disease called necrotizing fasciitis. Further, they proved that inactivating this section of the gene lessens the devastating disease in humans.

Rosetta Puts Blood-Based Cancer Screen on Back Burner to Refocus on miRNA Diagnostics (GenomeWeb News)
Rosetta Genomics this month announced that it has scaled back its work on a serum-based colon cancer-screening assay based on microRNA biomarkers, less than a year after the company said that commercialization of the test, dubbed miRscreen Colon, had become its top priority.

Genomics Hits The Farm (Forbes)
Genomics is just starting to improve human health. But it has revolutionized dairy farming.

Decoding the Tasmanian Devil's Deadly Cancer (Time Magazine)
First discovered in 1996, the Tasmanian devil's deadly face cancer has spread swiftly through its population. If it's not stopped, the devils could go extinct in 35 years

Isis Pharmaceuticals Inc. (ISIS) Director, COO B Lynne Parshall sells 7,090 Shares (Guru Focus)
By insider. Director, COO of Isis Pharmaceuticals Inc. ( ISIS ) B Lynne Parshall sells 7,090 shares of ISIS on 12/31/2009 at an average price of $11.21 a share. Read more » »

Tasmanian devil cancer advances made (UPI)
MELBOURNE, Dec. 31 (UPI) -- Australian scientists say they are a step closer to diagnosing and vaccinating against a puzzling facial cancer driving Tasmanian devils toward near-extinction.


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