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Concordia granted $22M to study reusable fuels
Two Concordia University researchers have been awarded $22 million to study ways to transform agricultural and forestry waste into reusable fuels. The grants to Dr. Adrian Tsang and Vincent Martin of the Centre for Structural and Functional Genomics, announced this morning in Saskatoon by Science and Technology Minister Gary Goodyear, are the largest ever by Genome Canada to investigate ... (Mon, 20 Apr 2009 16:38:43 GMT)
NCI Director John E. Niederhuber's Address to the American Association for Cancer Research on Plan to Accelerate ...
Note: These remarks are as prepared and actual delivered speech may contain slight variations. Ray, thank you for the kind and generous introduction. This has been a great year for AACR. Your presidency has brought energy and vision to our beloved organization. (Mon, 20 Apr 2009 17:57:51 GMT)
Tracking down viruses that cause human disease
Narrator: This is Science Today. Using a genomics-based approach, scientists at the University of California, San Francisco are tracking down viruses that cause human disease. (Mon, 20 Apr 2009 18:03:46 GMT)
Expression Pathology Raises $6.5 Million to Develop Personalized Medicine Assays for Protein Biomarkers in FFPE Tissue
clinical and clinical biomarker research spur new financing (Mon, 20 Apr 2009 18:08:00 GMT)
NCI to Use Budget Bump to Expand Genomics, PHC
NEW YORK (GenomeWeb News) – The National Cancer Institute has put in place its outline for how it plans to spend the three percent increase it received in the 2009 budget and the extra funding it expects to receive from the American Recovery and Reinvestment Act, NCI Director John Niederhuber said today. (Mon, 20 Apr 2009 19:47:54 GMT)
Divergence Gets $500K Grant for RNAi Nematode Research
NEW YORK (GenomeWeb News) – Divergence, a St. Louis-based biotech firm developing agricultural genomic products, has received a $500,000 grant from the National Science Foundation to continue research into biotech traits for lesion nematode control in crops, such as corn. (Mon, 20 Apr 2009 19:48:03 GMT)
Canada Awards $91M for Genomics Projects
NEW YORK (GenomeWeb News) – Genome Canada said today that it, along with national and international partners, has awarded C$112 million ($90.7 million) in new grants for genomics and proteomics studies of crop plants and bioproducts. (Mon, 20 Apr 2009 19:48:14 GMT)
NHGRI Releases Free Phenotype Toolkit
NEW YORK (GenomeWeb News) – The National Human Genome Research Institute today launched the first version of a free, online toolkit of phenotypic data. (Mon, 20 Apr 2009 19:48:23 GMT)
Expression Analysis, RainDance Offer Cancer Collaboration
NEW YORK (GenomeWeb News) – Expression Analysis and RainDance Technologies will collaborate to offer researchers services that can characterize rare genetic mutations relevant to complex diseases, particularly cancer, Expression Analysis said today. (Mon, 20 Apr 2009 19:48:33 GMT)
Funding Update
The PI is investigating the collision-induced dissociation of peptides and whether a rearrangement process that some peptide and protein fragments undergo during CID can result in lost sequence information. (Mon, 20 Apr 2009 19:48:43 GMT)
Concordia University receives more than $22 million for genomics research
( Concordia University ) Dr. Tsang was awarded $17.4 million for his project on the discovery of novel approaches for biofuel production. (Mon, 20 Apr 2009 20:13:21 GMT)
Study Findings Have Implications for Development of Pain-Relieving Drugs
Morphine and other opioids are widely used to treat both acute and chronic pain - yet their benefits are often limited because some people experience side effects or do not respond to them efficiently. (Mon, 20 Apr 2009 20:33:51 GMT)
Products & Services
The Pachyonychia Congenita Project is organizing a meeting next month focused on delivering functionally active nucleic acids, including siRNAs, into the skin. (Mon, 20 Apr 2009 20:47:53 GMT)
Divergence to be major tenant at BRDG Park at the Danforth Plant Science Center
Bio-Research & Development Growth (BRDG) Park at the Danforth Plant Science Center, which will open in June 2009 the first of three buildings for plant and life sciences research companies, announced that Divergence, Inc. (Mon, 20 Apr 2009 20:49:38 GMT)
How cells change gears: New insights published in Nature Genetics
( University of California - San Diego ) Bioinformatics researchers from UC San Diego just moved closer to unlocking the mystery of how human cells switch from "proliferation mode" to "specialization mode." This computational biology work from the Jacobs School of Engineering's bioengineering department could lead to new ideas for curbing unwanted cell proliferation -- including some cancers. ... (Mon, 20 Apr 2009 21:34:49 GMT)
How cells change gears
Bioinformatics researchers from UC San Diego just moved closer to unlocking the mystery of how human cells switch from "proliferation mode" to "specialization mode." This computational biology work from the Jacobs School of Engineering's bioengineering department could lead to new ideas for curbing unwanted cell proliferation -including some cancers. This research, published in Nature Genetics, ... (Mon, 20 Apr 2009 21:48:26 GMT)
Psoriasis associated with diabetes and high blood pressure in women
Women with psoriasis appear to have an increased risk for developing diabetes and hypertension (high blood pressure), according to a report in the April issue of Archives of Dermatology. (Mon, 20 Apr 2009 23:18:36 GMT)
Huntington Disease Begins To Take Hold Early On
A global analysis of brain proteins over a 10-week period in a mouse model of Huntington disease has revealed some new insights into this complex neurodegenerative disorder. (Mon, 20 Apr 2009 23:23:04 GMT)
Molecular profiling helps cancer patients survive
Cancer patients can survive longer under treatments based on their individual genetic profiles, according to a nationwide study released jointly today by Phoenix-area healthcare organizations. (Tue, 21 Apr 2009 00:21:08 GMT)
Discovery of possible way to block the spread of deadly brain tumors
Researchers at the Translational Genomics Research Institute (TGen) may have found a way to stop the often-rapid spread of deadly brain tumors. (Tue, 21 Apr 2009 00:21:42 GMT)
University helps earthquake stricken academics continue vital research
Long-standing collaborative research at the earthquake devastated University of L'Aquila will continue thanks to the Faculty of Medicine. (Tue, 21 Apr 2009 01:57:17 GMT)
The University Times | The University of North Carolina at Charlotte's Student Newspaper Since 1949
The Department of Bioinformatics and Genomics, and BioCytics, a privately owned company based out of Huntersville, North Carolina, have come together to collaborate on a cancer research project. (Tue, 21 Apr 2009 02:31:17 GMT)
The University Times | The University of North Carolina at Charlotte's Student Newspaper Since 1949
The Department of Bioinformatics and Genomics, and BioCytics, a privately owned company based out of Huntersville, North Carolina, have come together to collaborate on a cancer research project. (Tue, 21 Apr 2009 03:46:18 GMT)
Low Volume SPE Assays Enhanced By Novel C18 Sorbent
Porvair Sciences Ltd. has announced the availability of a new range of BioVyon C18 silica columns and microplates for use in low volume Solid Phase Extraction (SPE) assays. (Tue, 21 Apr 2009 06:15:26 GMT)
Researchers identify genes that protect ageing process
Scientists at the University of Liverpool have developed a new method to help researchers identify genes that can help protect the body during the ageing process. (Tue, 21 Apr 2009 06:36:28 GMT)
Study findings have implications for development of pain-relieving drugs
Morphine and other opioids are widely used to treat both acute and chronic pain – yet their benefits are often limited because some people experience side effects or do not respond to them efficiently. (Tue, 21 Apr 2009 06:36:41 GMT)
Genes that protect against aging identified
Washington, Apr 21 : University of Liverpool researchers have developed a novel method to help scientists identify genes that can help protect the body during the ageing process. (Tue, 21 Apr 2009 09:46:28 GMT)
Nonlinear Dynamics Announce New Versions of the Progenesis Range for Reproducible Proteomics
NEWCASTLE UPON TYNE, England----Nonlinear Dynamics Ltd, the world leading developer of analysis solutions for proteomics and biomarker discovery has launched new versions of all the products in its innovative Progenesis range. (Tue, 21 Apr 2009 10:00:00 GMT)
NuGEN Expands Product Portfolio with New Applause Brand RNA Amplification Products
SAN CARLOS, Calif.----NuGEN Technologies, Inc., a leader in nucleic acid amplification and sample preparation, announced today that it has employed its powerful, Single Primer Isothermal Amplification technology to create a new line of products that offers life scientists a fast, simple, and low-cost solution for routine gene expression analysis. (Tue, 21 Apr 2009 10:00:00 GMT)
Researchers identify genes that protect during ageing
London, April 21 : A new method developed by scientists will help researchers isolate genes that can protect the body during the ageing process. (Tue, 21 Apr 2009 10:47:53 GMT)
Roche NimbleGen and Sigma-Aldrich Collaborate to Advance Epigenetic Research
MADISON, Wis. & ST. LOUIS----Roche NimbleGen and Sigma-Aldrich have started a collaboration to further chromatin immunoprecipitation-on-microarray research by aligning their two complementary technologies, Roche NimbleGen's ChIP-chip high-density microarrays and GenomePlex by Sigma-Aldrich. (Tue, 21 Apr 2009 12:00:00 GMT)
Xennex Inc. Providing Satoris Inc. With Latest GeneCards(R) Tools For Characterization Of Protein Biomarkers ...
Xennex Inc. (Xennex) announced that it is collaborating with Satoris Inc. (Satoris) and has provided Satoris with access to GeneCards(R) and associated proprietary tools, including GeneAlaCart and early access to input from the advanced prototype of GeneCards(R) version 3.0, which is in advanced stages of development. (Tue, 21 Apr 2009 12:23:45 GMT)
Eureka to Utilize Best-in-Class Illumina Genome Analyzer Technology At Newly Launched Eureka Genomics Center
HERCULES, Calif., April 21, 2009 -- Privately held Eureka Genomics, which applies its proprietary functional genomics platform technology to the analysis of complex biological systems to enable rapid pathogen analysis, and to inform the discovery and development of diagnostic, biopharma and cleantech products, announced that it is launching its first Eureka Genomics Center in North America. (Tue, 21 Apr 2009 12:30:00 GMT)
Arrayit Speeds Analysis of the Human Genome
Arrayit Corporation, a life sciences and healthcare technology leader, announces a scientific breakthrough that accelerates the analysis of the human genome. The scientific discovery by Arrayit scientists, which combines advances in surface chemistry, bioinformatics, instrumentation and microarray technology, reduces the time required to analyze the human genome from several days to less than ... (Tue, 21 Apr 2009 13:18:00 GMT)
Arrayit Speeds Analysis of the Human Genome
SUNNYVALE, CA--(Marketwire - April 21, 2009) - Arrayit Corporation ( OTCBB : ARYC ), a life sciences and healthcare technology leader, announces a scientific breakthrough that accelerates the analysis of the human genome. The scientific discovery by Arrayit scientists, which combines advances in surface chemistry, bioinformatics, instrumentation and microarray technology, reduces the time ... (Tue, 21 Apr 2009 13:32:01 GMT)
Nanobac Pharmaceuticals Merger Partner Eureka to Utilize Best-In-Class Illumina Genome Analyzer Technology at Newly ...
TAMPA, FL--(Marketwire - April 21, 2009) - Nanobac Pharmaceuticals, Inc. ( PINKSHEETS : NNBP ) and its privately held merger partner Eureka Genomics, which applies its proprietary functional genomics platform technology to the analysis of complex biological systems to enable rapid pathogen analysis, and to inform the discovery and development of diagnostic, biopharma and cleantech products, ... (Tue, 21 Apr 2009 14:00:00 GMT)
New Online 'Toolkit' Aims To Standardize Measures, Protocols Scientists Use In Genetic Studies
Starting today, scientists who conduct genetic studies will have a new set of "tools" to refine estimates of disease risk and extend the findings of one study to other studies or across population groups. (Tue, 21 Apr 2009 14:07:27 GMT)
Coherent Announces High-Power Yellow Lasers For Bioimaging And Cytometry
Coherent, Inc. has unveiled a new series of yellow (561 nm) lasers that produce higher power and offer greater efficiency than anything previously available at this wavelength... (Tue, 21 Apr 2009 14:27:55 GMT)
Expression Pathology Gets $6.5M Investment from Abraxis
NEW YORK (GenomeWeb News) – Expression Pathology, a Gaithersburg, Md.-based developer of technology for analyzing protein biomarkers in tissue, has received $6.5 million in financing from biopharmaceutical firm Abraxis BioScience. (Tue, 21 Apr 2009 14:48:23 GMT)
You Can't Be Too Careful
Daniel MacArthur at Genetic Future blogs about a new " inquiry into personalised medicine " started by the Nuffield Council on Bioethics, a British think tank. (Tue, 21 Apr 2009 14:48:54 GMT)
Step Right Up
BBC reports that researchers have kicked off a project aiming "to link the migration of men in the Bronze Age to the discovery of copper" -- for which they'll need DNA samples to help trace the predicted trail of Mediterranean people to northwest Wales some 4,000 years ago. (Tue, 21 Apr 2009 14:49:04 GMT)
This Week in PNAS
Publishing in the online edition last week, research led by Vamsi Mootha and Sarah Calvo at the Broad Institute performed a genome-wide analysis of upstream ORFs and how they affect global protein expression. (Tue, 21 Apr 2009 15:02:55 GMT)
New Insights Published In Nature Genetics On How Cells Change Gears
Bioinformatics researchers from UC San Diego just moved closer to unlocking the mystery of how human cells switch from "proliferation mode" to "specialization mode." This computational biology work from the Jacobs School of Engineering's bioengineering department could lead to new ideas for curbing unwanted cell proliferation - including some cancers. (Tue, 21 Apr 2009 15:09:06 GMT)
Bad Day for Ethanol Precipitation
Nick Oswald at Bitesize Bio considers a study of various approaches to desalting DNA for electroporation and concludes that "for the high concentration samples the microcolumns were the clear winner, although dialysis and gel filtration gave just a 2-fold lower efficiency." (Tue, 21 Apr 2009 15:17:54 GMT)
FANTOM Findings Boost For Biologists
Genomic regulatory blocks have unique features that may explain their ability to respond to regulatory inputs from very long distances, according to a special thematic series of companion articles from the FANTOM4 consortium. (Tue, 21 Apr 2009 16:09:18 GMT)
Discovery of Group of Proteins Associated With Pediatric MS Could Lead to New Disease Diagnostics
A group of 12 proteins associated with pediatric multiple sclerosis (MS) have been discovered for the first time by a team of neurology and pathology researchers at Stony Brook University Medical Center. Led by Lauren Krupp, M.D., Director of the National Pediatric MS Center at SBUMC, the finding could lead to a new panel of diagnostic and prognostic markers in pediatric MS. (Tue, 21 Apr 2009 16:33:31 GMT)
Genes That Protect Against Aging Identified By Study
Scientists at the University of Liverpool have developed a new method to help researchers identify genes that can help protect the body during the ageing process. The team developed a method of analysing genes in multiple ageing tissue types in both animals and humans. (Tue, 21 Apr 2009 17:08:06 GMT)
Paired Ends
Dietrich Stephan has joined the scientific advisory board of Mitrionics , which provides parallel processing software and accelerated hybrid computing servers. (Tue, 21 Apr 2009 18:02:53 GMT)
Satoris to Use Xennex Database
NEW YORK (GenomeWeb News) – Satoris will use Xennex's GeneCards database and other tools in its biomarker studies, under a new agreement announced by Xennex today. (Tue, 21 Apr 2009 19:48:13 GMT)
People in the News
Combimatrix said this week that Karine Hovanes has joined its subsidiary, Combimatrix Molecular Diagnostics, as its laboratory director. (Tue, 21 Apr 2009 20:02:56 GMT)
IP Roundup
PerkinElmer has received US Patent No. 7,521,245, "Method for washing and drying pins in microarray spotting instruments." The patent claims an apparatus that includes an array of chambers, each for receiving one of the pins of a spotting instrument. (Tue, 21 Apr 2009 20:17:53 GMT)
New Product Watch
NuGen Technologies this week launched its WT-Amp ST and WT-Amp Plus ST RNA Amplification Systems , designed to prepare cDNA targets for analysis using Affymetrix GeneChip Gene ST or Exon ST arrays , respectively. (Tue, 21 Apr 2009 20:18:14 GMT)
FDA May Issue More White Papers on Rx/Dx Codevelopment, Woodcock Says At Meeting
The US Food and Drug Administration may issue a series of white papers outlining the most up-to-date knowledge on drug/diagnostic codevelopment, a top agency official said at a recent conference. (Tue, 21 Apr 2009 20:18:23 GMT)
Firms That Sell Arrayers Continue to See 'Strong' Demand Despite Market Downturn
While the current economic climate has hastened the demise of several biotech firms in recent weeks, such as DNAPrint Genomics and Codon Devices, companies that sell instruments for making microarrays say that their market segment has remained intact, and that they are actually seeing a rise in demand for their products. (Tue, 21 Apr 2009 21:03:07 GMT)
Max Planck Team Develops Sample-Prep Method that Promises to Aid Study of Complex Proteomes
Researchers at the Max Planck Institute for Biochemistry have devised a sample-preparation method combining the advantages of in-gel and in-solution digestion methods for mass spectrometry-based proteomics that they said could become a "crucial" technology for research into complex proteomes. (Tue, 21 Apr 2009 21:03:19 GMT)
Illumina Posts 36 Percent Rise in Q1 Revenues; Ups '09 Guidance
NEW YORK (GenomeWeb News) – Illumina reported after the close of the market on Tuesday that its first-quarter revenues increased 36 percent year over year. (Tue, 21 Apr 2009 22:17:53 GMT)
Hats off for giving new life to old fungi
Two Concordia University researchers have been awarded $22 million to study ways to transform agricultural and forestry waste into reusable fuels. (Tue, 21 Apr 2009 23:53:44 GMT)
Helmsley grant funds launch of Salk Center for Nutritional Genomics
Courtesy Salk Institute for Biological Studies PRESS RELEASE The Salk Institute has received a $5.5 million grant from the Leona M. and Harry B. Helmsley Charitable Trust to launch the Salk Center for Nutritional Genomics. The new Center will employ a molecular approach to nutrition and its impact on the role of metabolism on the immune system, cancer, diabetes and lifespan, thereby increasing ... (Tue, 21 Apr 2009 23:56:08 GMT)
New insights into transcription factors in human cells
Bioinformatics researchers from UC San Diego just moved closer to unlocking the mystery of how human cells switch from "proliferation mode" to "specialization mode." (Wed, 22 Apr 2009 00:50:58 GMT)
Putting The "Bio" Into Bioinformatics
Bioinformatic analyses have grown rapidly in sophistication and efficiency to accommodate the explosion in available DNA sequences. As the reliance on molecular data in biology and medicine increases, we need to be confident that these methods capture the underlying processes of genome change. (Wed, 22 Apr 2009 10:06:45 GMT)
Cardiff University Becomes a GeneGo Center of Excellence
GeneGo, Inc., a leading provider of software and databases for systems biology and pathway analysis, today announced that the University of Cardiff has become a certified GeneGo Center of Excellence. (Wed, 22 Apr 2009 11:00:00 GMT)
Six New Genes Associated with Heart Attacks
SANTA CLARA, Calif.----Affymetrix, Inc. today announced that its GeneChip® genotyping technology played a part in the recently announced discoveries of six new genes associated with susceptibility to heart attacks. (Wed, 22 Apr 2009 12:00:00 GMT)
Roche Nimblegen And Sigma-Aldrich Collaborate To Advance Epigenetic Research
Roche NimbleGen and Sigma-Aldrich (Nasdaq: SIAL) have started a collaboration to further chromatin immunoprecipitation-on-microarray (ChIP-chip) research by aligning their two complementary technologies, Roche NimbleGen's ChIP-chip high-density microarrays and GenomePlex by Sigma-Aldrich. (Wed, 22 Apr 2009 12:03:37 GMT)
Personalized Medicine Helps Cancer Patients Survive
Cancer patients can survive longer under treatments based on their individual genetic profiles, according to a nationwide study released jointly by Phoenix-area healthcare organizations. (Wed, 22 Apr 2009 12:24:36 GMT)
Expression Pathology lands $6.5M for personalized medicine assays
ROCKVILLE, MD - Expression Pathology Inc., a developer of technology for tissue protein analysis, has received financing of $6.5 million, led exclusively by Abraxis BioScience, a global biotechnology company. (Wed, 22 Apr 2009 12:26:25 GMT)
Roche Nimblegen And Sigma-Aldrich Collaborate To Advance Epigenetic Research
Roche NimbleGen and Sigma-Aldrich (Nasdaq: SIAL) have started a collaboration to further chromatin immunoprecipitation-on-microarray (ChIP-chip) research by aligning their two complementary technologies, Roche NimbleGen's ChIP-chip high-density microarrays and GenomePlex by Sigma-Aldrich. (Wed, 22 Apr 2009 12:55:24 GMT)
Genes Identified That Enhance Tumor Cell Sensitivity To CTI's Cancer Drug Brostallicin
Systems Medicine, LLC (SM), a wholly-owned subsidiary of Cell Therapeutics, Inc. (Wed, 22 Apr 2009 13:24:26 GMT)
Organizers Chart TCGA Progress at AACR
DENVER (GenomeWeb News) – As researchers get ready to wrap up the pilot phase of the Cancer Genome Atlas later this year, they're gearing up for the second phase of the project, which will likely involve sequencing roughly 20 to 25 tumor types in the next five years. (Wed, 22 Apr 2009 14:32:53 GMT)
Madrid Genetics Institute Installs CapitalBio Array Platform
NEW YORK (GenomeWeb News) – Spain's Institute of Molecular and Medical Genetics, or INGEMM, has purchased a CapitalBio Array Platform through the distributor Biotools, Biotools said today. (Wed, 22 Apr 2009 14:33:13 GMT)
Eurogentec to Distribute Olink's Proteomics Technology
NEW YORK (GenomeWeb News) - Olink Bioscience said this seek that Eurogentec of Liège, Belgium, will distribute its Duolink in situ Proximity Ligation Assay product line in Germany, France, Belgium, Luxembourg, the Netherlands, Switzerland, Austria, and the Czech Republic. (Wed, 22 Apr 2009 14:33:23 GMT)
UK Bioethics Group Mulls Consumer Genomics
NEW YORK (GenomeWeb News) – A UK biomedical ethics group has started a consultation program with stakeholders in biomedical business and research to gather information on perceptions of personalized healthcare technologies, including DNA testing, body imaging, and telemedicine. (Wed, 22 Apr 2009 14:33:33 GMT)
Discovery Of Group Of Proteins Associated With Pediatric MS Could Lead To New Disease Diagnostics
A group of 12 proteins associated with pediatric multiple sclerosis (MS) have been discovered for the first time by a team of neurology and pathology researchers at Stony Brook University Medical Center. Led by Lauren Krupp, M.D., Director of the National Pediatric MS Center at SBUMC, the finding could lead to a new panel of diagnostic and prognostic markers in pediatric MS. (Wed, 22 Apr 2009 15:09:21 GMT)
MPI and MDC Researchers Make Significant Strides in Identifying Cause of Bacterial Infections
Several bacterial pathogens use toxins to manipulate human host cells, ultimately disturbing cellular signal transduction. Until now, however, scientists have been able to track down only a few of the proteins that interact with bacterial toxins in infected human cells. (Wed, 22 Apr 2009 15:19:58 GMT)
German researchers make significant strides in identifying cause of bacterial infections
( Helmholtz Association of German Research Centres ) Several bacterial pathogens use toxins to manipulate human host cells, ultimately disturbing cellular signal transduction. Until now, however, scientists have been able to track down only a few of the proteins that interact with bacterial toxins in infected human cells. Now, researchers in Germany have identified 39 interaction partners of ... (Wed, 22 Apr 2009 16:13:28 GMT)
AltheaDx Expands Genotyping Menu for Drug Metabolism
AltheaDx announced today the launch of its Affymetrix Drug Metabolizing Enzymes & Transporter genotyping microarray service. The new service provides biopharmaceutical clients with the world's most comprehensive way to measure the genetics of drug metabolism in clinical trial patients -- giving drug developers the opportunity to select patients that are more likely to respond. (Wed, 22 Apr 2009 16:16:00 GMT)
AltheaDx Expands Genotyping Menu for Drug Metabolism
New Microarray Offering Expands Existing Capabilities With Affymetrix' Drug Metabolizing Enzymes and Transporters (DMET Plus) for Comprehensive Genetic Studies of Pharmacokinetics (Wed, 22 Apr 2009 16:30:09 GMT)
InteRNA, Radboud University Collaborate on miRNA Rx for Prostate Cancer
InteRNA Technologies and Radboud University Nijmegen Medical Centre said today that they have agreed to collaborate on the development of microRNA-based therapeutics for prostate cancer. (Wed, 22 Apr 2009 16:33:03 GMT)
IP Update
"Efficient sequence-specific gene silencing is possible through the use of siRNA technology," the patent's abstract states. "By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene-silencing reagent, as well as methods for silencing genes. (Wed, 22 Apr 2009 16:33:09 GMT)
New Releases
According to the company, the new service provides biopharmaceutical clients with "a way to measure the genetics of drug metabolism in clinical trial patients — giving drug developers the opportunity to select patients that are more likely to respond." (Wed, 22 Apr 2009 17:18:41 GMT)
CORPORATE
PERFORMANCE: ACC profit increases on higher volumes in Q1 Consolidated turnover up 14% at Rs 2,164 cr. Mumbai, April 22 Higher volume and stringent cost control initiatives have enabled cement major ACC Ltd to post increased profits for the first quarter (January-March) ... (Wed, 22 Apr 2009 18:14:04 GMT)
$10 million Simons Foundation gift supports new initiative with Institute for Advanced Study
( Rockefeller University ) The Rockefeller University and the Institute for Advanced Study in Princeton, N.J., have established a joint initiative in biology supported by a $10 million gift from the Simons Foundation. (Wed, 22 Apr 2009 19:13:19 GMT)
Salk Lands $5.5M Grant for Nutritional Genomics
NEW YORK (GenomeWeb News) – The Salk Institute today said that it will use a $5.5 million grant from the Leona M. and Harry B. Helmsley Charitable Trust to create a center to study nutritional genomics. (Wed, 22 Apr 2009 19:17:53 GMT)
Fluxion Taps EuroClone as Distributor
NEW YORK (GenomeWeb News) – EuroClone will distribute Fluxion Biosciences' microfluidic platform in a number of European countries under an exclusive agreement, Fluxion said Tuesday. (Wed, 22 Apr 2009 19:18:13 GMT)
Virco Lab to Market SmartGene's HIV Platform
NEW YORK (GenomeWeb News) – HIV resistance testing company Virco Lab will market SmartGene's web-based data management module to HIV researchers. (Wed, 22 Apr 2009 19:18:23 GMT)
PENN Medicine News: A Biological Basis for the 8-Hour Workday? Penn Researchers uncover 8- and 12-hour Cycles of Gene ...
PHILADELPHIA - The circadian clock coordinates physiological and behavioral processes on a 24-hour rhythm, allowing animals to anticipate changes in their environment and prepare accordingly. (Wed, 22 Apr 2009 19:47:11 GMT)
Waters, University of Warwick Collaborate to Build Out Applications for Synapt Platform
Waters and the University of Warwick in the UK last week announced a collaboration aimed at expanding applications for the company's Synapt HDMS platform and other Waters mass specs. (Wed, 22 Apr 2009 19:47:53 GMT)
Discovery of 12 proteins associated with pediatric multiple sclerosis
A group of 12 proteins associated with pediatric multiple sclerosis (MS) have been discovered for the first time by a team of neurology and pathology researchers at Stony Brook University Medical Center. (Wed, 22 Apr 2009 21:36:12 GMT)
A Biological Basis for the 8-Hour Workday? Researchers uncover 8- and 12-hour Cycles of Gene Activity
(PhysOrg.com) -- The circadian clock coordinates physiological and behavioral processes on a 24-hour rhythm, allowing animals to anticipate changes in their environment and prepare accordingly. Scientists already know that some genes are controlled by the clock and are turned on only one time during each 24-hour cycle. (Wed, 22 Apr 2009 22:03:46 GMT)
Ensembl Genomes Expands and Tackles Growing Sequencing Data
Bio-IT World | As large scale genome sequencing becomes more common, the “sheer volume of data is presenting a major challenge,” Paul Kersey, leader of the Ensembl Genomes team at EMBL-EBI, told Bio-IT World . (Wed, 22 Apr 2009 22:31:34 GMT)
Discovering Genes That Protect Against Aging
Scientists have developed a new method to help researchers identify genes that can help protect the body during the aging process. (Thu, 23 Apr 2009 01:36:42 GMT)
Affy Posts $25M Net Loss for Q1
NEW YORK (GenomeWeb News) – Affymetrix reported after the close of the market on Wednesday that its first-quarter product and services revenue increased 7 percent year over year, but a profit in the first quarter of 2008 swung to a $25 million net loss. (Thu, 23 Apr 2009 03:02:55 GMT)
CSUCI adds new stem cell research curriculum
A new course of study at California State University Channel Islands this fall will train students to conduct research that could lead to cures for diabetes, spinal cord injuries or cancer. (Thu, 23 Apr 2009 03:30:28 GMT)
Depression (major depression)
Dr. Daniel Hall-Flavin, board certified in general psychiatry and addiction psychiatry, is a St. Louis native looking to the Internet as a way to help people improve their health and be more active participants in their own health care by learning from Mayo Clinic's experts. (Thu, 23 Apr 2009 08:02:33 GMT)
Teams of Scientists in Singapore and Hungary Collaborate to Discover Cures and Therapies to Advance Healthcare Delivery
Singapore's Agency for Science, Technology and Research (A*STAR) and Hungarys National Office for Research and Technology (NKTH) awarded grants to four new research projects in cancer, bio-imaging for stem cell therapy, stroke rehabilitation and drug delivery at the 2nd Singapore-Hungary Joint Symposium held in Singapore today. (Thu, 23 Apr 2009 08:10:36 GMT)
X PRIZE Foundation and Knome Spotlight DNA Day With Historic Charity Auction of Whole Genome Sequence
PLAYA VISTA, Calif.----To spotlight National DNA Day, which will be celebrated on April 25, The X PRIZE Foundation, an educational nonprofit prize institute dedicated to fostering radical breakthroughs for the benefit of humanity, and Knome, Inc., a leading personal genomics company, today announced a first of its kind charity auction. (Thu, 23 Apr 2009 09:13:00 GMT)
Glycos Biotechnologies and Eureka Genomics Work Together to Sequence Proprietary Bacterium to Support Emerging ...
HOUSTON----Glycos Biotechnologies, Inc. , a pioneer in metabolic engineering, and Eureka Genomics, a leader in analysis of next generation genomic sequencing data, announced today the sequencing of the genome of a proprietary bacterium that will support the growth of the emerging biorefinery industry. (Thu, 23 Apr 2009 12:30:00 GMT)
Celera Presents Data Describing An Immunodiagnostic Assay To Detect Lung Cancer From Blood Serum
Celera Corporation (NASDAQ:CRA) announced the presentation of data describing a novel mass spectrometry-based approach to identify and validate circulating protein biomarkers that detect non-small cell lung cancer (NSCLC). (Thu, 23 Apr 2009 13:17:52 GMT)
Nanobac Pharmaceuticals Merger Partner, Eureka Genomics, and Glycos Biotechnologies Work Together to Sequence ...
Nanobac Pharmaceuticals merger partner Eureka Genomics, a leader in analysis of next generation genomic sequencing data and Glycos Biotechnologies, Inc., a pioneer in metabolic engineering, announced today the sequencing of the genome of a proprietary bacterium that will support the growth of the emerging biorefinery industry. (Thu, 23 Apr 2009 13:45:00 GMT)
Nanobac Pharmaceuticals Merger Partner, Eureka Genomics, and Glycos Biotechnologies Work Together to Sequence ...
Bacterium Designed to Convert Both Cellulosic Sugars to Advanced Ethanol and Biochemicals (Thu, 23 Apr 2009 13:57:22 GMT)
Good News, HapMap: We Still Need You
Dan Koboldt has a blog post at MassGenomics about how HapMap data is still useful , despite concerns that it would be made obsolete by the 1,000 Genomes Project. (Thu, 23 Apr 2009 14:33:53 GMT)
And We Thought It Was to Scan Things Faster at the Supermarket
T. Ryan Gregory is a happy man. Over at Genomicron he blogs about a special issue of the journal Molecular Ecology Resources focusing on DNA barcoding. He links to all of the papers, which are open access. (Thu, 23 Apr 2009 14:34:03 GMT)
Luminex Corporation First Quarter Earnings Release Scheduled for May 7, 2009
AUSTIN, Texas----Luminex Corporation today announced that it expects to report first quarter results on Thursday, May 7, 2009. Results are scheduled for release after the close of trading. (Thu, 23 Apr 2009 15:00:00 GMT)
New Products
Nonlinear Dynamics this week introduced new versions of its Progenesis LC-MS , Progenesis MALDI , and Progenesis SameSpots software. (Thu, 23 Apr 2009 15:32:54 GMT)
This Week in Nature
A news story in Nature this week reports on the FANTOM consortium , which used high-throughput sequencing to create a timeline of mRNA produced by human leukemia cells in response to the presence of phorbol myristate acetate. (Thu, 23 Apr 2009 16:03:00 GMT)
New cow genome sequence released
( BioMed Central ) Scientists from the University of Maryland have published their assembly of the domestic cow (Bos taurus), an important new resource for the genetics community. The new version of the cow genome improves considerably on other assemblies, in terms of both completeness and accuracy. The article describing their research is freely available in BioMed Central's open-access journal ... (Thu, 23 Apr 2009 16:13:24 GMT)
Progress for Clinical Trials
From 1983 to 2004, James Doroshow was chairman of the City of Hope Comprehensive Cancer Center's Department of Medical Oncology and Therapeutics Research. (Thu, 23 Apr 2009 16:47:53 GMT)
People in the News
According to the company, the prize was awarded for Tillman's work published last year in the Journal of Pharmaceutical Sciences related to the oral delivery of antisense oligonucleotides. (Thu, 23 Apr 2009 17:03:07 GMT)
Sequencing the cow's genetic code -- a new agricultural era dawns
( Swiss Institute of Bioinoformatics ) Researchers from the Universities of Geneva and Lausanne, as well as the Swiss Institute of Bioinformatics have been part of a major international project to sequence the bovine genome. (Thu, 23 Apr 2009 18:14:38 GMT)
A Biological Basis for the 8-Hour Workday?
Scientists already know that some genes are controlled by the circadian clock and are turned on only one time during each 24-hour cycle. Now, researchers have found that some genes are switched on once every 12 or 8 hours, indicating that shorter cycles of the circadian rhythm are also biologically encoded. (Thu, 23 Apr 2009 18:25:12 GMT)
A Biological Basis for the 8-Hour Workday?
Scientists already know that some genes are controlled by the circadian clock and are turned on only one time during each 24-hour cycle. Now, researchers have found that some genes are switched on once every 12 or 8 hours, indicating that shorter cycles of the circadian rhythm are also biologically encoded. (Thu, 23 Apr 2009 18:29:32 GMT)
Expression Pathology Nabs $6.5M Investment from Abraxis to Develop Cancer Drug-Response Dxs
Sample-preparation firm Expression Pathology announced two developments this week that could help build its diagnostic pipeline. (Thu, 23 Apr 2009 18:47:54 GMT)
Sigma's Q1 Revenues Hit by Negative Currency Effects
NEW YORK (GenomeWeb News) - Sigma-Aldrich today reported a 9 percent drop in revenues for the three months ended March 31, while net income was flat year-over-year. (Thu, 23 Apr 2009 19:18:04 GMT)
Asterand to Validate Abcam’s Antibodies
NEW YORK (GenomeWeb News) – Asterand said today that it will validate and characterize antibodies and immunohistochemistry applications for antibody marketer Abcam. (Thu, 23 Apr 2009 19:18:14 GMT)
Sequenom to Lay Off 30 Staffers to Cut Costs
NEW YORK (GenomeWeb News) – Sequenom said today that it will lay off 30 employees — around 12 percent of its staff — in an effort to reduce costs. (Thu, 23 Apr 2009 19:32:55 GMT)
A genomic CluE for cloud computing
( University of Maryland ) University of Maryland computer science researchers recently received a grant from the National Science Foundation Cluster Exploratory Program to fund research aimed at discovering how remote cluster computers, computer networks available over the internet, might be used to process DNA sequence data. (Thu, 23 Apr 2009 19:53:06 GMT)
Strategic Diagnostics to Report First Quarter Results on April 30, 2009
NEWARK, Del.----Strategic Diagnostics Inc. - a leading provider of biotechnology-based detection solutions for a broad range of food, water, agricultural, industrial, environmental and scientific applications, expects to release its first quarter 2009 results at approximately 4 p.m. (Thu, 23 Apr 2009 20:02:00 GMT)
A genomic CluE for cloud computing
DNA sequencing is the next frontier in biological research. As new sequencing technology becomes more efficient and affordable, it is increasingly available to small laboratories. Thus, sequencing data is being generated at a faster rate than ever before. (Thu, 23 Apr 2009 20:15:46 GMT)
Knome and X Prize Foundation to Sell Personal Genome Sequence at Auction; Bidding Starts at $68K
Personal genomics company Knome and the X Prize Foundation are jointly auctioning off sequencing and analysis services for an individual's genome, the partners said today. (Thu, 23 Apr 2009 20:32:53 GMT)
Beyond associations: Colorectal cancer culprit found
( Cold Spring Harbor Laboratory ) Genetics plays a key role in risk for colorectal cancer, the second leading cause of cancer-related deaths in the United States. Several genetic markers are associated with the disease, but finding the biological events that lead to cancer is much more difficult. In a study published online in Genome Research, scientists identified a common genetic variation ... (Thu, 23 Apr 2009 21:23:37 GMT)
Learning on the job
An undergraduate employment program is eliminating the need for some students to stack supermarket shelves or clean houses at the same time as enriching their studies. By Genevieve Costigan. (Fri, 24 Apr 2009 00:57:46 GMT)
Declining System Sales Drag Cepheid Q1 Revenues Down 13 Percent
NEW YORK (GenomeWeb News) – Cepheid reported on Thursday afternoon that its first-quarter revenue fell 13 percent year over year, largely due to a 45 percent drop in system sales. (Fri, 24 Apr 2009 01:47:53 GMT)
UC Davis-led research consortium explores milk genome
Findings paint a vivid picture of the molecular evolution of milk and lactation. (Fri, 24 Apr 2009 07:03:44 GMT)
Scientists unravel cow genome
Washington, Apr 24 : An international team of scientists has successfully sequenced cow's genome, thus paving the way for more sustainable food production. (Fri, 24 Apr 2009 09:36:14 GMT)
BGI buys additional 12 Genome Analyzers from Illumina
Illumina, Inc announced that BGI purchased 12 additional Genome Analyzers, expanding their installed base of Illumina's next-generation sequencing platforms to 29 units. (Fri, 24 Apr 2009 09:48:25 GMT)
Teams Of Scientists In Singapore And Hungary Collaborate To Discover Cures And Therapies To Advance Healthcare Delivery
Singapore's Agency for Science, Technology and Research (A*STAR) and Hungarys National Office for Research and Technology (NKTH) awarded grants to four new research projects in cancer, bio-imaging for stem cell therapy, stroke rehabilitation and drug delivery at the 2nd Singapore-Hungary Joint Symposium held in Singapore today. (Fri, 24 Apr 2009 11:19:32 GMT)
A crash course in emerging technologies
Singularity n. A point of infinite density and infinitesimal volume, at which space and time become infinitely distorted according to the theory of General Relativity. According to the big bang theory, a gravitational singularity existed at the beginning of the universe. (Fri, 24 Apr 2009 12:02:23 GMT)
Six New Genes Associated With Heart Attacks
Affymetrix, Inc. (Nasdaq:AFFX) announced that its GeneChip® genotyping technology played a part in the recently announced discoveries of six new genes associated with susceptibility to heart attacks. Scientists from the University of Lübeck, Germany, and Massachusetts General Hospital, USA together with European and American colleagues, conducted three separate studies. (Fri, 24 Apr 2009 12:20:49 GMT)
NSF Awards Grant to U of Maryland for Cloud-Based Next-Gen Sequence Analysis
NEW YORK (GenomeWeb News) – The National Science Foundation said today that it has awarded a research team at the University of Maryland a grant to develop software for next-generation sequence analysis that will run on the "cloud" — high-performance compute clusters that can be accessed over the Internet. (Fri, 24 Apr 2009 13:47:53 GMT)
$500K DoD Grant Supports Ovarian Cancer Consortium
NEW YORK (GenomeWeb News) – The National Functional Genomics Center will use funding from the US Military to run a collaborative project focused on finding genetic variations involved in ovarian cancer. (Fri, 24 Apr 2009 14:18:16 GMT)
USDA awards grants to ISU for genomic research, Extension
USDA awards grants to ISU for genomic research, Extension Iowa The U.S. Department of Agriculture has awarded competitive grants to Iowa State University for projects in animal genomics research and Extension. The three Iowa State projects were awarded grants through the National Research Initiative Animal Genome Program, which seeks to develop sound, practical, science-based knowledge that can ... (Fri, 24 Apr 2009 14:38:37 GMT)
Sound the Alert: It's DNA Day Eve!
Here at GenomeWeb we can barely contain ourselves: it's almost DNA Day! In fact, with DNA Day falling on a Saturday this year, several organizations are actually celebrating today. (Fri, 24 Apr 2009 14:47:53 GMT)
Come into Our Parlor, Dr. Felsenstein
Over at Dechronization, Luke Harmon posts an interview with phylogenetics expert Joe Felsenstein , a professor in the genome sciences department at the University of Washington. (Fri, 24 Apr 2009 14:48:05 GMT)
Soon They'll Be Selling Knockoff Genomes on the Streets of Manhattan
Sandra Porter has a blog post at Discovering Biology in a Digital World about the cost of genome sequencing and why it's plummeted as fast as it has . "CoFactor Genomics will sequence a human genome (at 1.6X coverage) for $22,900. Knome is putting a human genome on EBay with bids starting at $68,000," she writes. (Fri, 24 Apr 2009 14:48:13 GMT)
Rock Out, Darwin
John Dennehy at The Evilutionary Biologist lets readers know about an upcoming series of concerts called Darwin Live , performed by anthropologist Richard Milner (as Dennehy refers to him, "the foremost practitioner of Darwinian entertainment"). (Fri, 24 Apr 2009 14:48:23 GMT)
This Week in Science
An editorial from Ralph Cicerone , president of the US National Academy of Sciences, says that scientists will have to do their part to keep enthusiasm for science on the upswing in this country. (Fri, 24 Apr 2009 15:17:53 GMT)
A Biological Basis For The 8 Hour Workday?
The circadian clock coordinates physiological and behavioral processes on a 24-hour rhythm, allowing animals to anticipate changes in their environment and prepare accordingly. Scientists already know that some genes are controlled by the clock and are turned on only one time during each 24-hour cycle. (Fri, 24 Apr 2009 15:20:36 GMT)
Downloads & Updgrades
The European Bioinformatics Institute has released Ensembl Bacteria , Ensembl Protists , and Ensembl Metazoa — the first sites under EBI's " Ensembl Genomes " project to extend the use of the Ensembl browser to non-vertebrate genomes. (Fri, 24 Apr 2009 16:33:26 GMT)
People in the News
Dietrich Stephan has joined the scientific advisory board of Mitrionics , which provides parallel processing software and accelerated hybrid computing servers based on FPGA technology. (Fri, 24 Apr 2009 16:33:30 GMT)
Microsoft Names UAB Team a U.S. Finalist in Global Technology Competition
A team of three University of Alabama at Birmingham (UAB) students has been named a U.S. finalist in the seventh annual Microsoft-sponsored Imagine Cup competition. The team, from the Department of Computer and Information Sciences (CIS) in the School of Natural Sciences and Mathematics, is one of just 15 U.S. finalists in the competition's software design challenge. The U.S. finalists will be ... (Fri, 24 Apr 2009 16:34:43 GMT)
Eight Indian scientists honoured for groundbreaking research
Eight of India's leading scientists were Friday honoured with Thomson Reuters Research Excellence - India Research Front Awards for their groundbreaking work and influential contribution to global research and development. (Fri, 24 Apr 2009 16:44:50 GMT)
Sequencing The Cow's Genetic Code - A New Agricultural Era Dawns
Researchers from the Universities of Geneva and Lausanne, as well as the Swiss Institute of Bioinformatics have been part of a major international project to sequence the bovine (cow) genome, a female Hereford cow named L1 Dominette. (Fri, 24 Apr 2009 17:04:32 GMT)
Bioinformatics Briefs
Simulations Plus said this week that the National Cancer Institute has awarded it a two-year, $525,000 Phase II Small Business Innovation Research grant to further develop its ADMET Predictor software. (Fri, 24 Apr 2009 17:33:09 GMT)
Funding Update
Supports development of MGTAXA, a freely available software and Web server for taxonomic classification of metagenomic sequences with machine learning techniques. (Fri, 24 Apr 2009 17:47:53 GMT)
MCW, Insilicos Enable Open Source Proteomics Tools for Data Analysis on the Cloud
Proteomics researchers who don't have access to high-performance computers now have several new options for running their data analysis on Amazon's Elastic Compute Cloud platform. (Fri, 24 Apr 2009 18:33:17 GMT)
Proteomics Software Firms Adjust Pricing Models to Help Researchers Cut Costs
As budgets tighten in many labs , some proteomics software firms are changing the way they deliver services and how they offer new software or features for current packages. (Fri, 24 Apr 2009 18:47:53 GMT)
Egyptian Biotech Group Seeks ‘Omics Partners
NEW YORK (GenomeWeb News) – The Egyptian Organization for Biotechnology and Vaccines is seeking partners to work with it on a variety of research program areas focused largely on genotyping and pharmacogenetics in cancer and in autoimmune diseases, the European Commission said this week. (Fri, 24 Apr 2009 19:03:03 GMT)
In Brief This Week: Celera, Eureka Genomics, Knome; Genomic Health, and more
NEW YORK (GenomeWeb News) – Celera presented data at the annual American Association for Cancer Research meeting describing its mass spectrometry-based approach to identify and validate circulating protein biomarkers that detect non-small cell lung cancer. (Fri, 24 Apr 2009 19:03:13 GMT)
People in the News
NEW YORK (GenomeWeb News) - CombiMatrix has named Karine Hovanes to serve as lab director for its CombiMatrix Molecular Diagnostics subsidiary. (Fri, 24 Apr 2009 19:03:23 GMT)
Around the Regions
The first-ever economic impact study of the life sciences industry in Georgia was released earlier this week by GeorgiaBio, the Peachtree State's life sciences industry group, in association with the Selig Center for Economic Growth at the University of Georgia's Terry College of Business. (Fri, 24 Apr 2009 19:32:53 GMT)
Judge Nixes Dako’s Motion against UC, Abbott in FISH Patent Suit
NEW YORK (GenomeWeb News) – A California judge has denied a motion by Dako for summary judgment in a patent infringement case against the University of California and Abbott related to in situ DNA hybridization methods. (Fri, 24 Apr 2009 19:47:53 GMT)
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