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John Maddox Dies
John Maddox, a Nature editor for 22 years, died, reports Edge. He was 84. John Brockman writes , "John Maddox was a dominant figure in a golden age of science. (Mon, 13 Apr 2009 15:47:11 GMT)
Saving the Trouble
Bora Zivkovic rounds up a discussion he sparked the other day after posting an article that said in the Canadian grant system, the cost of preparing a grant application (C$40,000) outweighed the amount of an average grant (C$30,000). The article then suggested to give "every qualified investigator a direct baseline discovery grant of $30,000." Zivkovic discusses where the quality control would ... (Mon, 13 Apr 2009 15:47:13 GMT)
Scaling Up
Deepak Singh writes that big science will, "out of sheer necessity," need to use scalable designs for computing. From reading James Hamilton's blog , Singh writes that scaling comes from partitioning and redundancy while from Dan Reed's blog , Singh finds that the degree of parallel systems needed will be a challenge. (Mon, 13 Apr 2009 15:47:23 GMT)
Fort Detrick scientist honored for bioinformatics
FREDERICK, Md. (AP) - A civilian computer scientist at Fort Detrick in Frederick is being honored for work that has dramatically accelerated the pace of biodefense research. (Mon, 13 Apr 2009 15:50:04 GMT)
Nanobac Pharmaceutical advances merger with Eureka Genomics
Nanobac Pharmaceutical Inc. and Eureka Genomics signed a definitive merger agreement. (Mon, 13 Apr 2009 15:54:07 GMT)
The Ontario Cancer Biomarker Network Selects GenoLogics' Proteomics Lab and Data Management Solution
Vancouver, BC, April 13, 2009--(T-Net)--GenoLogics, a leading developer of informatics solutions for translational research, announced it is working with the Ontario Cancer Biomarker Network to deploy its lab and proteomics data management system. (Mon, 13 Apr 2009 16:00:53 GMT)
Fort Detrick scientist honored for bioinformatics
A civilian computer scientist at Fort Detrick is being honored for work that has dramatically accelerated the pace of biodefense research (Mon, 13 Apr 2009 16:28:10 GMT)
Papers of Note
Experimental Brain Research , March 4, 2009; epub ahead of print Islamov et al. Journal of General Virology , March 4, 2009; epub ahead of print Xia et al. (Mon, 13 Apr 2009 18:46:14 GMT)
NHLBI to Start Third Proteomics Program
With its two major proteomics programs winding down, the National Heart, Lung, and Blood Institute is embarking on its next major program, which calls for researchers to develop proteomics technologies and apply them to solve clinical puzzles. (Mon, 13 Apr 2009 19:16:19 GMT)
Cloud Computing Brings Cost Of Protein Research Down To Earth
Researchers have developed a set of free tools called ViPDAC (virtual proteomics data analysis cluster), for use in combination with Amazon's inexpensive "cloud computing" service, providing the option to rent processing time on its powerful servers; and free software, to put this very expensive and promising field within reach of scientists everywhere. (Mon, 13 Apr 2009 19:28:31 GMT)
Nanobac, Eureka Genomics Ink Definitive Merger Deal
NEW YORK (GenomeWeb News) – Nanobac Pharmaceuticals and Eureka Genomics have inked a definitive merger pact, under which Eureka shareholders will own 85 percent of the merged firm. (Mon, 13 Apr 2009 19:31:27 GMT)
NIH to Fund Biomarker Research for Alternative Medicine
NEW YORK (GenomeWeb News) – The National Center for Complementary and Alternative Medicine wants researchers to develop new tools to study complementary and alternative medical (CAM) approaches, including new biomarkers that are linked to well-being and stress. (Mon, 13 Apr 2009 19:31:37 GMT)
NICHD Starts New PGx Program
NEW YORK (GenomeWeb News) - The National Institutes of Health will support pharmacogenomics research aimed at understanding drug effects on, and targeting drugs for, children and pregnant women under a new program. (Mon, 13 Apr 2009 19:46:13 GMT)
Q&A: Pancreatic Cancer Biomarker 'Compendium' Foreshadows Future Web Portal
In a step toward a web-based database of all molecular alterations in pancreatic cancer, a team of researchers led by Johns Hopkins University's Akhilesh Pandey has mined the scientific literature to create of a "compendium" of potential biomarkers for pancreatic cancer. (Mon, 13 Apr 2009 23:01:13 GMT)
Stellar Pharmaceuticals Cash Positive for 2008
Stellar Pharmaceuticals Inc., a Canadian pharmaceutical developer and marketer of high quality, cost-effective products for select health care markets, today announced financial results for the year ended December 31, 2008. (Mon, 13 Apr 2009 23:07:00 GMT)
Prometheus puts $8m into Rosetta
Specialty pharmaceuticals maker Prometheus Laboratories is investing $8 million in Rosetta Genomics, at a premium of 42% over the Israeli company's share price. (Mon, 13 Apr 2009 23:17:48 GMT)
Stellar Pharmaceuticals Cash Positive for 2008
LONDON, ONTARIO--(Marketwire - April 13, 2009) - Stellar Pharmaceuticals Inc. (OTCBB:SLXCF) ("Stellar" or "the Company"), a Canadian pharmaceutical developer and marketer of high quality, cost-effective products for select health care markets, today announced financial results for the year ended December 31, 2008. This is the second consecutive year that the company has generated positive cash ... (Mon, 13 Apr 2009 23:22:29 GMT)
April 14, 2009 ENMU briefs
ENMU student Noel Hunt has been named Mrs. New Mexico and is running for Mrs. United States. Michael R. Elrod, president of ENMU-Ruidoso, has announced that he will retire next January. (Tue, 14 Apr 2009 06:02:04 GMT)
Medical College Of Wisconsin's Data Analysis Cluster Makes Proteomics Research More Accessible To Scientists Worldwide
Researchers at the Medical College of Wisconsin Biotechnology and Bioengineering Center in Milwaukee have just made the very expensive and promising area of protein research more accessible to scientists worldwide. (Tue, 14 Apr 2009 10:14:33 GMT)
Bioinformatics Tool-Related Papers of Note, July and August 2007
Bhave SV, Hornbaker C, Phang TL, Saba L, Lapadat R, Kechris K, Gaydos J, McGoldrick D, Dolbey A, Leach S, Soriano B, Ellington A, Ellington E, Jones K, Mangion J, Belknap JK, Williams RW, Hunter LE, Hoffman PL, Tabakoff B. (Tue, 14 Apr 2009 11:31:22 GMT)
Complete Genomics wants to sequence thousands of human genomes
The BBC reports that Complete Genomics, a biotech research firm in California, says that it will sequence one thousand complete human genomes between June 2009 and the end of the... (Tue, 14 Apr 2009 14:26:37 GMT)
In Print
Journal: Bioinformatics . 2009 Mar 15;25(6):751-7. Title: Statistical methods of background correction for Illumina BeadArray data. Authors: Y Xie; X Wang; M Story (Tue, 14 Apr 2009 19:16:13 GMT)
More Work Needed to Standardize Consumer Genomics Offerings, Top US Health Official Says
Although players in the burgeoning consumer genomics industry have agreed to standardize certain parts of their genetic risk screening offerings, they have yet to agree on clinical validation issues critical to protecting the public health, according to a top US government health official. (Tue, 14 Apr 2009 20:01:48 GMT)
Clinical Data, Inc. Completes Sale of Cogenics Genomics Services Division to Beckman Coulter, Inc.
NEWTON, Mass.----Clinical Data, Inc. announced today that it has completed the sale of Cogenics, the Company's genomics services division, to Beckman Coulter, Inc. for $17.0 million. (Tue, 14 Apr 2009 20:38:00 GMT)
Backed by New Investors, LightSpeed Genomics Plans to Test its Detection Tech for Sequencing
After going through a restructuring phase at the end of last year in which it temporarily laid off its entire staff, LightSpeed Genomics has secured new investors and continues to develop its optical-detection technology, which it plans to integrate with a new sequencing chemistry this year, In Sequence has learned. (Tue, 14 Apr 2009 21:01:15 GMT)
Q&A: Method Developed by Burnham Institute Team IDs 95 Percent of Fission Yeast Proteome
Name : Dieter Wolf Position : Director, NCI Cancer Center Proteomics Facility, Burnham Institute for Medical Research, 2007 to present; professor of signal transduction program, Burnham Institute, 2007 to present. (Tue, 14 Apr 2009 21:01:25 GMT)
Science Magazine to Host Webinar on Advances in Cancer Genomics
The business office of Science, the world's leading peer-reviewed research journal, is partnering with Applied Biosystems, a division of Life Technologies Corporation, to produce a webinar on Advances in Cancer Genomics to be broadcast live online at 12 noon ET (4:00 GMT) April 30, 2009. (Wed, 15 Apr 2009 07:01:00 GMT)
Recent Patents of Interest in Proteomics
US Patent 7,519,514. Systems and methods for removing noise from spectral data. Inventor: Randy Keith Roushall. Assignee: Agilent Technologies (Wed, 15 Apr 2009 18:31:43 GMT)
A bright future for biological sensors
In the future, explained Peter Ghazal, Chair of Edinburgh University's Department of Molecular Genetics and Biomedicine, biological sensors, the product of the integration of biology and electronics will be used to detect infections and prescribe personalized treatments. (Thu, 16 Apr 2009 05:58:14 GMT)
BioTek Instruments And Promega Simplify The Determination Of Cell-Based Mechanisms Of Toxicity With Automated Solutions
BioTek Instruments along with Madison, Wisconsin based Promega Corporation, demonstrate the use of Promega's microwell cell-based assays in a triplex format to generate more biologically relevant data per single well with straightforward and cost-effective automated systems such as BioTek's Precision™ Automated Microplate Pipetting Systems. (Thu, 16 Apr 2009 09:25:12 GMT)
Essential Resources for Modern Biology
3rd Biocuration Conference in Berlin on April 16-19 - Introducing a new International Society for Biocuration (ISB) Life is data. Lots of data. The findings of biologists are presented in the scientific literature and in very large data sets stemming from experiments. (Thu, 16 Apr 2009 09:48:21 GMT)
Creativity Awards From Prostate Cancer Foundation For BIDMC Scientists
Two projects led by scientists at Beth Israel Deaconess Medical Center (BIDMC) have received funding from the Prostate Cancer Foundation (PCF) as part of their 2009 Creativity Awards program, which supports innovative ideas to improve the detection and treatment of prostate cancer. The one-year awards were made to 10 projects at nine institutions throughout the U.S. (Thu, 16 Apr 2009 11:13:40 GMT)
German Gov’t Grants Cellzome $4.9M to Expand Kinobeads Into New Rx Classes
Cellzome last week said it plans to use a €3.5 million ($4.9 million) grant from the German government to broaden its proteomics technology for use in epigenetics-based drug discovery, and to “miniaturize” the platform for use on patient biopsies. (Thu, 16 Apr 2009 12:16:13 GMT)
BioAdvance Names Dr. Philip P. Gerbino Chair and Elects Dr. John M. Daly to Board of Directors
PHILADELPHIA----BioAdvance, the Biotechnology Greenhouse Corporation of Southeastern Pennsylvania, today announced that Philip P. Gerbino, PharmD., has been elected as Chair of the organization's Board of Directors effective April 2009. (Thu, 16 Apr 2009 12:30:00 GMT)
Biological Sensors Are The Future Of Personalized Treatment
Informatics is the foundation of research into biomedicine and nanomedicine In the future, explained Peter Ghazal, Chair of Edinburgh University's Department of Molecular Genetics and Biomedicine, biological sensors, the product of the integration of biology and electronics will be used to detect infections and prescribe personalized treatments. (Thu, 16 Apr 2009 14:23:58 GMT)
OHSU to Start NIAID Center
NEW YORK (GenomeWeb News) – The Oregon Health and Science University will use funding from the National Institutes of Allergy and Infectious Diseases to form a regional research center that will conduct a variety of studies on infectious diseases, including genomics research. (Thu, 16 Apr 2009 14:33:03 GMT)
This Week in Nature
In Nature early online this week, scientists used an RNAi screen in Drosophila to study the Notch signaling pathway during external sensory organ development. Their work identified six new genes involved in asymmetric cell division and 23 novel genes regulating the Notch pathway. (Thu, 16 Apr 2009 15:47:53 GMT)
JAMA Drama Continues
The drama at JAMA that began with Jonathan Leo asking the journal to look into Robert Robinson's ties to Forest Laboratories (Robinson published a paper in JAMA saying that Lexapro helped prevent depression in stroke victims) is continuing. (Thu, 16 Apr 2009 16:02:59 GMT)
What to Do With the GWAS
In three commentaries in the New England Journal of Medicine , Children's Hospital's Joel Hirschhorn, Duke's David Goldstein, and Harvard's Peter Kraft and David Hunter discuss the complexity basis of common genetic diseases. (Thu, 16 Apr 2009 16:03:15 GMT)
Smurf Genes Help Cells Find the Path Ahead
One sign that cells cannot tell front from back is disruption of the orderly hair cells inside the inner ear. In a normal embryonic mouse, hair cells are lined up in an orderly way so they can vibrate in response to sounds (left). (Thu, 16 Apr 2009 16:03:18 GMT)
Hair Metal Lives
What do power ballads and cell monitoring have in common? Check out this new viral marketing video from Roche. Hold on, we're looking for a lighter. (Thu, 16 Apr 2009 16:03:26 GMT)
Star with Darwin
If your on-camera persona is up to snuff, you could appear in a film about Charles Darwin , reports the Guardian . The Darwin Aloud project is calling for videos of people reading an excerpt from On the Origin of Species in their native language in front of a landmark, a scientifically important site, or other scenery. (Thu, 16 Apr 2009 16:03:37 GMT)
Why don't we share data?
There are so, so many reasons--and they make a lot of sense (Thu, 16 Apr 2009 16:07:18 GMT)
Olink, Abnova Ink Co-marketing Pact
NEW YORK (GenomeWeb News) – Olink Bioscience and Abnova have agreed to a co-development and co-marketing partnership for protein assays, Olink said today. (Thu, 16 Apr 2009 16:32:53 GMT)
Breakthrough Breast Cancer Research Centre Launches Free Database To Help Speed The Path To New Treatments
Breakthrough Breast Cancer has today launched the world's most comprehensive breast cancer database - bringing scientific research and clinical data together in one place. The Rock database is a free resource which allows scientists easy access to an enormous amount of published data on breast cancer. (Thu, 16 Apr 2009 17:07:26 GMT)
People in the News
Santaris Pharma has appointed Arthur Levin , its chief development officer, as president of its new California-based subsidiary. (Thu, 16 Apr 2009 17:32:55 GMT)
As Long as the Camel Doesn't Spit on the Date
Researchers at Cornell's campus in Qatar have mapped the date palm genome , according to the Gulf Times . "We have generated a draft DNA sequence and initial assembly of the date palm," Joel Malek says, a project that involved using next-gen sequencers. (Thu, 16 Apr 2009 17:33:05 GMT)
New Products
Ludesi this week launched Redfin Solo , its new 2D gel image-analysis software with a payment model that allows users to pay only for analyses they believe is of value to them. (Thu, 16 Apr 2009 17:47:53 GMT)
Movers & Shakers
Witney joins Dionex from Affymetrix where he was executive vice president and chief commercial officer. Prior to that he was president and CEO of Panomics from July 2002 until it was acquired by Affymetrix in December 2008. (Thu, 16 Apr 2009 17:48:03 GMT)
Analyst Speculates on Potential Thermo Fisher Acquisition
NEW YORK (GenomeWeb News) – Leerink Swann analyst Isaac Ro said in a research report published today that he believes a major acquisition by Thermo Fisher Scientific is "likely in the near term, with possible targets coming in the areas of Bioprocess tools, HPLC, or Diagnostics." (Thu, 16 Apr 2009 19:17:53 GMT)
Satoris, RayBiotech to Co-develop Alzheimer's Test
NEW YORK (GenomeWeb News) – Satoris will collaborate with RayBiotech to develop array-based test kits for Alzheimer's disease, the firms said today. (Thu, 16 Apr 2009 19:18:13 GMT)
Plant Breeder to Use Keygene's Tools
NEW YORK (GenomeWeb News) – Keygene said today that it has signed a long-term contract with Semillas Fitó under which it will develop and integrate its molecular tools into the plant-breeding company's programs. (Thu, 16 Apr 2009 19:18:23 GMT)
Huntington disease begins to take hold early on
( American Society for Biochemistry and Molecular Biology ) A global analysis of brain proteins over a 10-week period in a mouse model of Huntington disease has revealed some new insights into this complex neurodegenerative disorder. (Thu, 16 Apr 2009 19:53:31 GMT)
Huntington disease begins to take hold early on
A global analysis of brain proteins over a 10-week period in a mouse model of Huntington Disease has revealed some new insights into this complex neurodegenerative disorder. For example, profound changes (comparable to those seen in late-stage HD) actually occur well before any disease symptoms show up, and most of the changes are confined to a specific stage during disease progression. These ... (Thu, 16 Apr 2009 20:03:26 GMT)
Prodesse Gets FDA OK for C. Difficile Assay
NEW YORK (GenomeWeb News) – Prodesse announced after the close of the market Thursday that the US Food and Drug Administration has cleared for marketing the firm's ProGastro Cd Assay. (Thu, 16 Apr 2009 21:17:53 GMT)
University pursues stem cell research
A new course of study at California State University Channel Islands this fall will train students to conduct research that could lead to cures for diabetes, spinal cord injuries or cancer. The California Institute for Regenerative Medicine recently awarded the Camarillobased university a three-year, $1. (Fri, 17 Apr 2009 01:48:31 GMT)
Illumina Announces Scale-Up Of Its Genome Analyzer Sequencing Technology At The Broad Institute Of MIT And Harvard
Illumina, Inc. recently announced that the Broad Institute of MIT and Harvard has acquired 22 additional Genome Analyzers to increase its installed base of the Illumina sequencing platform to 47 units. (Fri, 17 Apr 2009 05:04:08 GMT)
Biotech sector grows by 20 pc
Biotech sector grows by 20 pcBiotech sector grows by 20 pc (Fri, 17 Apr 2009 12:38:07 GMT)
Two Indian firms to set up pre-clinical trials units in Malaysia
Two Indian firms to set up pre-clinical trials units in MalaysiaTwo Indian firms to set up pre-clinical trials units in Malaysia (Fri, 17 Apr 2009 12:41:04 GMT)
Software aids DNA copy number analysis, visualization.
Used for DNA copy number analysis of microarray-derived data, platform-independent Nexus Copy Number v4 provides algorithm for SNP arrays. It combines log ratio and B-allele frequency values to segment genome, detection of loss of hetrozygosity (LOH), and allelic imbalance calls for SNP array data, along with predictive power analysis for continuous data types, query tool for listing genomic ... (Fri, 17 Apr 2009 13:04:30 GMT)
A novel method of isolating high quality RNA from Kupffer cells
( World Journal of Gastroenterology ) A research group from United States developed a method of labeling and microdissecting mouse Kupffer cells within an extraordinarily short period of time using laser capture microdissection. This method provides an approach to isolating high quality RNAfrom Kupffer cells, without altering the tissue integrity. (Fri, 17 Apr 2009 13:08:31 GMT)
Then There's the Unique Species that Lives inNew York City Subways
This article in the Economist considers why rat control in Asia, where black rats are more common than the brown rats that spread in Europe, has been particularly difficult. (Fri, 17 Apr 2009 13:17:53 GMT)
Out of the Mouths of Babes
This month’s issue of the Journal of Clinical Microbiology contains results of a study to check out microbial communities found in the mouths of cavity-prone kids and their dentally immaculate peers. (Fri, 17 Apr 2009 13:18:03 GMT)
Unrecapping the Unconference
For those of us whose invitations to Sci Foo were lost in the mail, here's a way to catch up on the "unconference" put on by Nature Publishing Group, Google, and O'Reilly Media earlier this month. (Fri, 17 Apr 2009 13:18:23 GMT)
Qiagen Licenses HandyLab Extraction Technology
NEW YORK (GenomeWeb News) – HandyLab said this week that Qiagen has licensed the firm's extraction technology for use in the sample preparation part of its human papillomavirus assays. (Fri, 17 Apr 2009 14:32:54 GMT)
NCI to Fund Cancer Disparity Studies
NEW YORK (GenomeWeb News) – The National Institutes of Health is seeking to fund research into the causes and mechanisms involved in cancer health disparities, including gene expression and epigenetic studies and polymorphism research, through two new grant programs. (Fri, 17 Apr 2009 14:33:03 GMT)
DNAVision Gains Two New Certifications
NEW YORK (GenomeWeb News) – The genetic sequencing and genotyping company DNAVision said today that it has received accreditation from the commission on Laboratory Accreditation of the College of American Pathologists and received GMP certification from the Belgium Drug Federal Agency. (Fri, 17 Apr 2009 14:33:13 GMT)
Big Names Weigh In
While personal genomics companies say their tests have predictive value and will be helpful in health and wellness, The Economist asks what David Altshuler, Craig Venter, Russ Altman, George Church, and others think. (Fri, 17 Apr 2009 15:32:53 GMT)
Looking for a Fire Sale
The Wall Street Journal says to expect " an uptick in acquisitions of small and midsize drug companies" but that large pharma companies are "not going on reckless shopping sprees." (Fri, 17 Apr 2009 15:33:03 GMT)
"I Said, Young Man!"
Qian's lab is focused on better understanding cell signaling and discovering diagnostic protein biomarkers for human diseases, such as diabetes, through the development and application of novel mass spectrometry-based proteomics approaches capable of measuring changes in protein abundances and post-translational modifications from mammalian cells, tissues, and biofluids. (Fri, 17 Apr 2009 15:33:13 GMT)
A Regular Ray of Sunshine
At The Scientist , PNNL's Steven Wiley discusses why biological data isn't readily available online -- despite all the calls for it to be shared. (Fri, 17 Apr 2009 15:33:23 GMT)
This Week in Science
In early online, scientists have found that transposases play a role in one large eukaryotic genome. Studying the protozoan Oxytricha trifallax , which gets rid of 95 percent of its germline genome during development, they found that transposase genes play a key role in this process. (Fri, 17 Apr 2009 15:48:10 GMT)
A novel method of isolating high quality RNA from Kupffer cells
Kupffer cells, resident tissue macrophages that line the liver sinusoids, play a key role in modulating inflammation in a number of experimental models of liver injury. Since Kupffer cells represent only a small portion of the entire liver cell population, greatly outnumbered by the parenchymal cells, Kupffer cell isolation faces major technical obstacles. Laser capture microdissection (LCM) ... (Fri, 17 Apr 2009 16:18:36 GMT)
TGen researchers discover possible way to block the spread of deadly brain tumors
( The Translational Genomics Research Institute ) Researchers at the Translational Genomics Research Institute may have found a way to stop the often-rapid spread of deadly brain tumors. A gene with the playful-sounding name NHERF-1 may be a serious target for drugs that could prevent malignant tumors from rapidly multiplying and invading other parts of the brain, according to a cover story in ... (Fri, 17 Apr 2009 17:13:17 GMT)
Researchers find possible way to block the spread of deadly brain tumors
Researchers at the Translational Genomics Research Institute (TGen) may have found a way to stop the often-rapid spread of deadly brain tumors. (Fri, 17 Apr 2009 17:33:26 GMT)
People in the News
Protein Forest has appointed John Tonkinson to the newly created position of vice president of global sales and marketing. He will be responsible for expanding the company’s digital ProteomeChip and MSRAT data analysis software into global markets. (Fri, 17 Apr 2009 17:47:53 GMT)
Bioinformatics Briefs
NextBio said this week that it has been awarded a Small Business Innovation Research grant to incorporate genomic and proteomic information for vertebrates and plants in its NextBio data search and discovery platform. (Fri, 17 Apr 2009 18:17:53 GMT)
Bruker Warns Analysts of Single-Digit Q1 Revenue Decline
Bruker said yesterday that it expects revenues for the first quarter of 2009 to decline in the single digits. Adjusted for the effects of foreign exchange, revenues are expected to increase in the low single digits. (Fri, 17 Apr 2009 19:03:08 GMT)
NIH Grants will Support Early-Stage Science
NEW YORK (GenomeWeb News) – Under a grant program focused on early-stage ideas and technologies, the National Institutes of Health will give up to $275,000 over a two-year period to researchers seeking funding for potentially risky but rewarding studies. (Fri, 17 Apr 2009 19:17:54 GMT)
DiaTech Licenses Vanderbilt's Personalized Tumor Test
NEW YORK (GenomeWeb News) – DiaTech Oncology has struck a license agreement with Vanderbilt University for a microkinetic assay that can be used to determine a patient's chemotherapy treatment and dosing needs, the university said today. (Fri, 17 Apr 2009 19:18:03 GMT)
In Brief This Week: RainDance Technologies, Expression Analysis; BD; Precision Biomarkers, Affy; and More
NEW YORK (GenomeWeb News) – RainDance Technologies said this week that it had sold its RDT 1000 and sequence enrichment solution to Expression Analysis, a genomic services provider. RainDance said that it was the first sale of its system to a service provider. (Fri, 17 Apr 2009 19:33:03 GMT)
Dana-Farber, in Entrepreneurial Push, Founds Computational Biology Center
Boston's Dana-Farber Cancer Institute last week opened a pay-for-service, consulting-oriented computational biology center that will offer data analysis services to DFCI and external researchers. (Fri, 17 Apr 2009 20:03:08 GMT)
BioRegion Real Estate
During closing remarks at the 2009 Annual Meeting of the Massachusetts Biotechnology Council on April 14, Gov. Deval Patrick urged leaders from the life-sci sector and the state's largest unions to resolve differences over construction hiring and CEO compensation that have sparked a labor campaign against industry practices called "Stop Biotech Looting." (Fri, 17 Apr 2009 20:47:53 GMT)
Around the Regions
Maryland lawmakers earlier this week approved a $32.3 billion budget for the fiscal year starting July 1 that mostly satisfied the state's life sciences leaders by preserving intact funding for one key incentive program valued by the industry, while trimming spending for a second key program less than originally discussed. (Fri, 17 Apr 2009 20:48:03 GMT)
Delays in Safety Study Push Back Opening of BU's National Emerging Infectious Disease Lab
A study looking into the safety of Boston University's newly built National Emerging Infectious Disease Laboratory has been delayed, which has in turn pushed back to at least the coming fall a court decision on the fate of the facility. (Fri, 17 Apr 2009 21:03:16 GMT)
ASBMB Annual Meeting to feature talks on the biochemistry of aging
( American Society for Biochemistry and Molecular Biology ) Five-hundred years ago, Ponce de Leon combed the swamps of Florida seeking the legendary "fountain of youth." This week, at the 2009 ASBMB Annual Meeting in New Orleans (held in conjunction with Experimental Biology 2009) will feature a range of exciting talks centering on the new molecular "fountain of youth," the genes and pathways ... (Sat, 18 Apr 2009 04:13:17 GMT)
Venture Capital Investment Sinks to Lows Not Seen Since 1997
In the first quarter, only $3 billion was invested in 549 young companies, according to analysis by the National Venture Capital Association and PricewaterhouseCoopers. (Sat, 18 Apr 2009 04:26:17 GMT)
Guardian of the Fish With the Golden Eggs
Dr. Phaedra Doukakis is on a mission to protect the sturgeon, a fish particularly vulnerable because its eggs are used to make caviar. (Sat, 18 Apr 2009 04:49:28 GMT)
Library Journal honors two N.C. State librarians
Two N.C. State University staff members were named best in their field by Library Journal, a publication for professional librarians . Tina Adams was singled out as "Library Paraprofessional of the Year" for work she and the N.C. (Sat, 18 Apr 2009 06:02:17 GMT)
Possible way to block deadly brain tumor spread discovered
Washington, Apr 18 : A possible way to stop the often-rapid spread of deadly brain tumors has been found by researchers at the Translational Genomics Research Institute (TGen). (Sat, 18 Apr 2009 09:47:04 GMT)
Changes In Brain Discovered Long Before Huntington Disease Takes Hold
A global analysis of brain proteins over a 10-week period in a mouse model of Huntington Disease has revealed some new insights into this complex neurodegenerative disorder. For example, profound changes (comparable to those seen in late-stage HD) actually occur well before any disease symptoms show up, and most of the changes are confined to a specific stage during disease progression. (Sat, 18 Apr 2009 10:06:55 GMT)
Perhaps You Were Looking for a New Ringtone
It's Friday, so indulge GTO in this trip to the land of things that sound funny. First up, we've got another DNA-based song for your entertainment. (Sat, 18 Apr 2009 13:17:53 GMT)
One Blogger's Graph Theory
Not every scientist had the chance to study graphic design -- so how do all those graphs and illustrations come about in publications? Sometimes not easily. (Sat, 18 Apr 2009 13:18:03 GMT)
Try, Try, Try Again
Bucindolol, a beta-blocker that never made it to the market because a patient study showed it did not reduce the risk of death due to high blood pressure and heart failure, may be making a comeback. (Sat, 18 Apr 2009 13:18:13 GMT)
NIH Can Do Better
DrugMonkey answers questions that a blogger posted regarding underrepresented faculty and the NIH's policies on increasing funding for them. He says that underrepresentation of many ethnic minorities goes all up and down the academic ranks, not just at the PI level and suggests minorities check out the NIH program called Research Supplements to Promote Diversity in Health-Related Research. (Sat, 18 Apr 2009 13:18:23 GMT)
Newly discovered epidermal growth factor receptor active in human pancreatic cancers
( Federation of American Societies for Experimental Biology ) Finally some promising news about pancreatic cancer, one of the most fatal cancers, due to the difficulties of early detection and the lack of effective therapies: Johns Hopkins University pathologist Akhilesh Pandey has identified an epidermal growth factor receptor aberrantly active in approximately a third of the 250 human ... (Sat, 18 Apr 2009 15:09:19 GMT)
Geneva council gives RP good marks
COMPARED to other developing countries, the Philippines has a reasonable amount of internal funding, better infrastructure, higher health expenditures per capita, and more institutional capacity. (Sat, 18 Apr 2009 16:16:49 GMT)
Newly Discovered Epidermal Growth Factor Receptor Active In Human Pancreatic Cancers
Finally some promising news about pancreatic cancer, one of the most fatal cancers, due to the difficulties of early detection and the lack of effective therapies: Scientists have identified an epidermal growth factor receptor aberrantly active in approximately a third of the 250 human pancreatic cancers studied. (Sat, 18 Apr 2009 21:20:23 GMT)
Phoenix-based researchers pinpoint brain-cancer gene
Translational Genomics Research Institute researchers say they have pinpointed a gene that helps a deadly form of brain cancer spread, and the finding raises the potential of treating fatal brain tumors. (Sat, 18 Apr 2009 22:20:40 GMT)
Promising Interim Results From Hybrigenics' Inecalcitol Phase II In Combination With Taxotere(R) For ...
Hybrigenics (ALHYG), a bio-pharmaceutical company listed on Alternext (NYSE-Euronext) in Paris, with a focus on research and development of new cancer treatments and specialised in protein interactions, today announces preliminary results from its phase II clinical trial of inecalcitol in patients wi (Sun, 19 Apr 2009 11:07:56 GMT)
Q&A: Team Integrates Proteomics, MicroRNA Data to Find Osteoarthritis Gene Targets
In a study published online in PLoS One Nov. 17, researchers showed how they integrated microRNA and proteomics data to gain a better understanding of the molecular pathology of osteoarthritis. (Sun, 19 Apr 2009 14:18:03 GMT)
Vermillion, Tyrian Diagnostics, ABI, Invitrogen, Life Technologies, Bio-Rad, AnaSpec, Sunshine Bio Investments World
Vermillion last week said receipts rose to $71,000 for its third quarter, compared to no revenues during the year ago period. For the three months ended Sept. 30, the company posted $5,000 in product receipts and $66,000 in service-related revenues. (Sun, 19 Apr 2009 14:18:13 GMT)
California Names Companies Caught in Consumer Genomics Crackdown
NEW YORK (GenomeWeb News) – The California Department of Public Health has released the names of the 13 genetic testing companies that it has told to stop offering services in California, including several consumer genomics companies and other direct-to-consumer firms offering tests for particular conditions. (Sun, 19 Apr 2009 14:18:23 GMT)
Resolution: More Time to Blog in 2007
Computational biologist (and GT subscriber) Keith Robison of the Omics! Omics! blog reflects on his long career at Millennium, which is now ending. But there could be a silver lining for the rest of us if he increases the flow of posts like this one on Cyanophora paradoxa and the genomics of endosymbionts and organelles. (Sun, 19 Apr 2009 14:18:43 GMT)
Difficulties Abound
As part of its Evidence Gap series, the New York Times has a backgrounder on the obstacles facing personalized medicine -- getting pharmaceutical companies to develop tests, insurance companies to cover the cost, and doctors to order the test. (Sun, 19 Apr 2009 14:18:53 GMT)
Just Because You're Good at Something...
Title IX, the law prohibiting sex discrimination in education, has recently been extended to science . NSF, NASA, and the DOE have set up programs to look for sexual discrimination at universities receiving federal grants, the NYT reports. (Sun, 19 Apr 2009 14:19:05 GMT)
He Got Sidetracked by the Fabrication
In an ironic twist, discredited stem cell scientist Hwang Woo Suk might have actually performed a biological first . Instead of having isolated stem cells from a cloned human embryo as he claimed, an analysis of Hwang's work , published in Cell Stem Cell , shows that his lab made parthenogenic stem cells — thought to be incredibly difficult in humans. (Sun, 19 Apr 2009 14:19:13 GMT)
New Software Tool Lets Researchers Use R Across a Compute Cluster
In an effort to take advantage of the increasing pervasiveness of PCs with multicore processors and to help researchers thwart the high cost of software-based accelerators, researchers at the University of Edinburgh Medical School reached out to Jon Hill for some serious help using R. "They analyze genomic data and were starting to hit what their hardware could run in serial using R," says Hill, ... (Sun, 19 Apr 2009 15:17:53 GMT)
Auto students focused on $10M X Prize
With the Big 3 automakers on life support, a multimillion-dollar contest to create fuel-efficient cars is not just a lark for inventors - it could reveal the future of the industry. (Sun, 19 Apr 2009 19:19:15 GMT)
Personalized medicine helps cancer patients survive
( The Translational Genomics Research Institute ) Cancer patients can survive longer under treatments based on their individual genetic profiles, according to a nationwide study released jointly today by Phoenix-area health-care organizations.The study shows that molecular profiling of patients can identify specific treatments for individuals, helping keep their cancer in check for significantly ... (Sun, 19 Apr 2009 21:13:17 GMT)
Cancer research helps minimize toxic effects of chemotherapy
A TGen-Scottsdale Healthcare study shows how new screening tools help doctors decide which chemotherapy treatment to give patients based on their genetic makeup. (Sun, 19 Apr 2009 21:16:21 GMT)
Late-Breaking Science and Clinical Trials
As part of its efforts to showcase the latest breakthroughs in cancer science, the American Association for Cancer Research will host a press conference highlighting the newest research and clinical trial results from the AACR 100th Annual Meeting 2009. (Sun, 19 Apr 2009 21:33:28 GMT)
Personalized Medicine Helps Cancer Patients Survive
Cancer patients can survive longer under treatments based on their individual genetic profiles, according to a nationwide study. The study shows that molecular profiling of patients can identify specific treatments for individuals, helping keep their cancer in check for significantly longer periods and in some cases even shrinking tumors. (Sun, 19 Apr 2009 23:20:24 GMT)
New insights Huntington disease development
A global analysis of brain proteins over a 10-week period in a mouse model of Huntington Disease has revealed some new insights into this complex neurodegenerative disorder. (Mon, 20 Apr 2009 01:06:48 GMT)
Move over, Y chromosome - it's time X got some attention
In the first evolutionary study of the chromosome associated with being female, University of California, Berkeley, biologist Doris Bachtrog and her colleagues show that the history of the X chromosome is every bit as interesting as the much-studied, male-determining Y chromosome, and offers important clues to the origins and benefits of sexual reproduction. (Mon, 20 Apr 2009 02:06:08 GMT)
DNA analysis helps tailor cancer treatments
New study was driven by Valley researchers. (Mon, 20 Apr 2009 02:42:57 GMT)
Companies: News and notes from Vermont businesses
Spotlight on Vermont companies (Mon, 20 Apr 2009 08:29:21 GMT)
Will Ocean Plants Adapt To Climate Change?
How will plant cells that live in the oceans and serve as the basic food supply for many of the world's sea creatures react to climate change? Biologists came one step closer to answering that question in an article in the journal Science. (Mon, 20 Apr 2009 09:22:24 GMT)
Illumina and Agilent Technologies to Co-Market Targeted Resequencing Solution
SAN DIEGO & SANTA CLARA, Calif.----Illumina, Inc. and Agilent Technologies today announced they have entered into a non-exclusive co-marketing agreement to support a new, scalable solution for researchers conducting targeted resequencing studies. (Mon, 20 Apr 2009 10:00:00 GMT)
Dr. Karine Hovanes Named Laboratory Director of Combimatrix Molecular Diagnostics
MUKILTEO, Wash., April 20, 2009 -- CombiMatrix Corporation announced today that Dr. Karine Hovanes has joined its wholly owned subsidiary, Combimatrix Molecular Diagnostics , as its Laboratory Director. (Mon, 20 Apr 2009 10:00:00 GMT)
Newly Discovered Epidermal Growth Factor Receptor Active In Human Pancreatic Cancers
Finally some promising news about pancreatic cancer, one of the most fatal cancers, due to the difficulties of early detection and the lack of effective therapies: Johns Hopkins University pathologist Akhilesh Pandey has identified an epidermal growth factor receptor aberrantly active in approximately a third of the 250 human pancreatic cancers studied. (Mon, 20 Apr 2009 10:08:26 GMT)
Possible Way To Block The Spread Of Deadly Brain Tumors Discovered By TGen Researchers
Researchers at the Translational Genomics Research Institute (TGen) may have found a way to stop the often-rapid spread of deadly brain tumors. (Mon, 20 Apr 2009 10:08:56 GMT)
BGI Purchases an Additional 12 Illumina Genome Analyzers, Expanding Their Shenzhen and Hong Kong Branches
SAN DIEGO----Illumina, Inc. today announced that BGI purchased 12 additional Genome Analyzers, expanding their installed base of Illumina's next-generation sequencing platforms to 29 units. (Mon, 20 Apr 2009 10:30:00 GMT)
Personalized medicine helps cancer patients survive
Cancer patients can survive longer under treatments based on their individual genetic profiles, according to a nationwide study released jointly today by Phoenix-area healthcare organizations. (Mon, 20 Apr 2009 10:33:37 GMT)
Venture Capital Investment Sinks
Venture capital investment in the first quarter dropped to lows not seen since before the dot-com bubble, The New York Times’s Calire Cain Miller reported, citing an analysis of Thomson Reuters data. (Mon, 20 Apr 2009 10:46:22 GMT)
Rosetta Genomics to Give Oral Presentation on Colon Cancer Screening Diagnostic at AACR Annual Meeting
PHILADELPHIA & REHOVOT, Israel----Rosetta Genomics, Ltd. , an innovative molecular diagnostic company leveraging microRNAs as biomarkers, reports that at the annual meeting of the American Association of Cancer Research it will present data on its lead product candidate, a noninvasive diagnostic being developed for colon cancer screening. (Mon, 20 Apr 2009 11:00:00 GMT)
OncQuest launches new tests covering grey areas in cancer biology
After building trust with its innovative diagnostic tools, OncQuest Laboratories Ltd - the pioneer and the leader in the Indian Oncology clinical testing market, announced expansion of its test-range with the launch of new tests covering grey areas of cancer biology. (Mon, 20 Apr 2009 11:03:26 GMT)
Xennex Inc. Providing Satoris Inc. with Latest GeneCards(R) Tools for Characterization of Protein Biomarkers ...
Xennex Inc. announced today that it is collaborating with Satoris Inc. and has provided Satoris with access to GeneCards® and associated proprietary tools, including GeneAlaCart and early access to input from the advanced prototype of GeneCards® version 3.0, which is in advanced stages of development. (Mon, 20 Apr 2009 11:35:00 GMT)
Philadelphia auto students focused on $10 million X Prize
Philadelphia -- With the Big 3 automakers on life support, a multimillion-dollar contest to create fuel-efficient cars is not just a lark for inventors -- it could reveal the future of the industry. (Mon, 20 Apr 2009 11:43:45 GMT)
A Novel Method Of Isolating High Quality RNA From Kupffer Cells
Kupffer cells, resident tissue macrophages that line the liver sinusoids, play a key role in modulating inflammation in a number of experimental models of liver injury. Since Kupffer cells represent only a small portion of the entire liver cell population, greatly outnumbered by the parenchymal cells, Kupffer cell isolation faces major technical obstacles. (Mon, 20 Apr 2009 12:07:26 GMT)
Bioalma to Exhibit novo|seek at Bio-IT World Conference & Expo
Showcasing New Capabilities Including Ability to Search Grant Information; New Whitepaper on Text Mining-Based Search Approaches Available (Mon, 20 Apr 2009 12:58:41 GMT)
Chuck D, Indeed
Qian's lab is focused on better understanding cell signaling and discovering diagnostic protein biomarkers for human diseases, such as diabetes, through the development and application of novel mass spectrometry-based proteomics approaches capable of measuring changes in protein abundances and post-translational modifications from mammalian cells, tissues, and biofluids. (Mon, 20 Apr 2009 13:17:53 GMT)
Human Embryonic Stem Cell Guidelines Announced
NIH issued draft guidances on Friday regarding federal funding of research on human embryonic stem cells. The guidelines "allow funding for research using human embryonic stem cells that were derived from embryos created by in vitro fertilization for reproductive purposes and were no longer needed for that purpose." (Mon, 20 Apr 2009 13:18:03 GMT)
Media Advisory: Government of Canada and Genome Canada Announce New Agriculture and Bioproducts Research Projects
OTTAWA, ONTARIO--(Marketwire - April 20, 2009) - The Honourable Gary Goodyear, Minister of State, Science and Technology, and Dr. Calvin Stiller, Chairman of the Board of Directors of Genome Canada will announce the results of Genome Canada's Competition in Applied Genomics Research in Bioproducts or Crops during a news conference. /T/ Date: Monday, April 20, 2009 Time: 9:00 a.m. Location: ... (Mon, 20 Apr 2009 14:02:49 GMT)
This Week in PLoS
In PLoS One this week, research led in part by Harvard's Martha Bulyk found that short-term calorie restriction in male mice alters global gene expression patterns , making them more like those of female mice. (Mon, 20 Apr 2009 14:03:13 GMT)
Study identifies genes that protect against aging
( University of Liverpool ) Scientists at the University of Liverpool have developed a new method to help researchers identify genes that can help protect the body during the aging process. (Mon, 20 Apr 2009 14:24:00 GMT)
We're Hoping for More than "Please Reboot"
Tim O'Reilly blogs about the news that President Obama plans to nominate Aneesh Chopra to be the first US chief technology officer. (Mon, 20 Apr 2009 14:32:53 GMT)
Here's a Good Reason to Start Obeying the Speed Limit
The New York Times reports that FBI and state agencies in the US are " vastly expanding their collection of DNA to include millions more people who have been arrested or detained but not yet convicted." (Mon, 20 Apr 2009 14:33:03 GMT)
Illumina, Agilent in Resquencing Co-marketing Pact
NEW YORK (GenomeWeb News) – Illumina and Agilent have entered into a non-exclusive co-marketing agreement focused on researchers conducting targeted resequencing. (Mon, 20 Apr 2009 14:48:02 GMT)
Lander Talks Cancer Genomics at AACR Meeting
DENVER (GenomeWeb News) – Cancer research and genomics are intimately linked, Broad Institute Founding Director and Whitehead Institute for Biomedical Research member Eric Lander told researchers at the American Association for Cancer Research annual meeting in Denver this weekend. (Mon, 20 Apr 2009 14:48:03 GMT)
Alnylam Receives Intent-to-Grant Notice for European Patent Application
Alnylam Pharmaceuticals today announced that the European Patent Office has said it intends to grant it a patent broadly covering RNAi therapeutics. (Mon, 20 Apr 2009 14:48:14 GMT)
Government of Canada and Genome Canada Invest in Applied Genomics Research to Strengthen Canada's Agriculture, Crop ...
The Honourable Gary Goodyear, Minister of State, and Dr. Calvin Stiller, Chairman of the Board of Genome Canada, today announced 12 new genomics and proteomics research projects in the areas of bioproducts and crops. (Mon, 20 Apr 2009 15:00:00 GMT)
BGI Bolsters Stock of Illumina Sequencers
NEW YORK (GenomeWeb News) – The Beijing Genomics Institute has purchased 12 new Genome Analyzers for use in its Hong Kong and Shenzhen research centers, the company said today. (Mon, 20 Apr 2009 15:03:55 GMT)
NIH Offers Small Grants Program
NEW YORK (GenomeWeb News) – Researchers seeking small amounts of support for relatively short periods to fund short, well-defined studies that can be completed quickly, may apply to the National Institutes of Health for the Investigator Initiatives Small Grants program. (Mon, 20 Apr 2009 15:04:19 GMT)
Government of Canada and Genome Canada Invest in Applied Genomics Research to Strengthen Canada's Agriculture, Crop ...
SASKATOON, SASKATCHEWAN--(Marketwire - April 20, 2009) - The Honourable Gary Goodyear, Minister of State (Science and Technology), and Dr. Calvin Stiller, Chairman of the Board of Genome Canada, today announced 12 new genomics and proteomics research projects in the areas of bioproducts and crops. "Our government recognizes the important role that research excellence plays in furthering ... (Mon, 20 Apr 2009 15:15:16 GMT)
FANTOM findings boost for biologists
Genomic regulatory blocks have unique features that may explain their ability to respond to regulatory inputs from very long distances, according to a special thematic series of companion articles from the FANTOM4 consortium. This research, to be published across a number of BioMed Central's open-access journals, including Genome Biology and BMC Bioinformatics, provide further insight into HCNE ... (Mon, 20 Apr 2009 15:24:12 GMT)
New Online 'Toolkit' Aims to Standardize Measures, Protocols Scientists Use in Genetic Studies
Starting today, scientists who conduct genetic studies will have a new set of "tools" to refine estimates of disease risk and extend the findings of one study to other studies or across population groups. (Mon, 20 Apr 2009 15:32:41 GMT)
Study identifies genes that protect against aging
Scientists at the University of Liverpool have developed a new method to help researchers identify genes that can help protect the body during the ageing process. (Mon, 20 Apr 2009 16:03:37 GMT)
FANTOM findings boost for biologists
Genomic regulatory blocks have unique features that may explain their ability to respond to regulatory inputs from very long distances, according to a special thematic series of companion articles from the FANTOM4 consortium. This research, to be published across a number of BioMed Central's open access journals, including Genome Biology and BMC Bioinformatics, provide further insight into HCNE ... (Mon, 20 Apr 2009 16:18:46 GMT)
GO Terms Aim to Manage Microbe-Host Interactions
The Plant Associated Microbe Gene Ontology has added more than 700 words to an ongoing three-year Gene Ontology term-development initiative, and presented them as part of eight papers in a special supplement to BMC Microbiology. (Mon, 20 Apr 2009 16:32:53 GMT)
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