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Bioinformatics News 09/2008 (Page 3)

Genomics institute secures its future (Nature)
$400-million endowment edges Broad Institute towards independence.

The state of scripting (Java World)
The former second-class citizens of the programming world have leaped to the fore, changing the face of enterprise software development. With the rise of Web 2.0, scripting languages (also called dynamic languages) are now often considered important tools in a developer's arsenal.

Cancer complexity slows quest for cure (Nature)
Genomic analysis reveals multiple mutations in tumours.

Assistant Managing Editor (BioWorld)
ProMetic Life Sciences Inc. entered a potential $295 million licensing agreement with Abraxis BioScience to develop four products targeting undisclosed underserved medical conditions on a worldwide basis, excluding China and Taiwan.

25 Years Of Conventional Evaluation Of Data Analysis Proves Worthless In Practice (Science Daily)
So-called ‘intelligent’ computer-based methods for classifying patient samples, for example, have been evaluated with the help of two methods that have completely dominated research for 25 years. Now Swedish researchers are revealing that this methodology is worthless when it comes to practical problems.

Innate Immune System Targets Asthma-linked Fungus For Destruction (Science Daily)
A new study shows that the innate immune system of humans is capable of killing a fungus linked to airway inflammation, chronic rhinosinusitis and bronchial asthma. Researchers have revealed that eosinophils, a particular type of white blood cell, exert a strong immune response against the environmental fungus Alternaria alternata.

Synthetic Genomics Takes Top Spot on Cutting-Edge Cleantech List (GreenBiz)
SAUSALITO, Calif. -- A La Jolla, Calif.-based company trying to address environmental problems by engineering cellular "bio-factories" topped the cleantech heap on the 2008 GoingGreen 100 Top Private Companies list.

$400m gift makes center on genomics permanent (Boston Globe)
A record-setting $400 million gift announced yesterday will provide financial permanence for the Broad Institute, a Cambridge genomics research center that in just four years has become a worldwide leader in the effort to unravel the genetic basis of diseases.

New clues found to treat brain cancer (The Arizona Republic)
A Phoenix lab helped ID possible genetic causes.

Billionaires donate $400M to Mass. biomed institute (The Lewiston Sun Journal)
CAMBRIDGE, Mass. (AP) - Billionaire philanthropists Eli and Edythe Broad announced Thursday that they're adding $400 million to a joint biomedical venture at Harvard and MIT, saying they want to accelerate research into treatments for a slew of debilitating diseases.

Cancer Genome Atlas Reports Comprehensive Study of Brain Tumors (Kansas City InfoZine)
The Cancer Genome Atlas (TCGA) Research Network, a collaborative effort funded by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH), reported the first results of its large-scale, comprehensive study of the most common form of brain cancer, glioblastoma (GBM).

Invitrogen Names Joe Beery Senior Vice President, Chief Information Officer (Business Wire via Yahoo! Finance)
CARLSBAD, Calif.----Invitrogen Corporation , a provider of essential life science technologies for research, production and diagnostics, today announced the appointment of Joe Beery as head of Invitrogen’s Global Information Technology, effective September 8, 2008.

Rosetta Genomics Identifies Potential microRNA Biomarkers in Blood Serum (PR Newswire via Yahoo! Finance)
Rosetta Genomics, Ltd. , a leader in the development of microRNA-based diagnostic and therapeutic products, announced today that the results of a study conducted by its scientists describing the identification of microRNA biomarkers in blood serum, have been published online in the peer-reviewed journal PLOS One.

Interstate Rivalry Put On Hold By Stem Cell Research (Medical News Today)
Victoria and New South Wales have put aside their competitive interstate rivalry to collaborate on a stem cell research project, as announced by Innovation Minister Gavin Jennings and NSW Minister for Science and Medical Research, Verity Firth.

Invitrogen Names Joe Beery Senior Vice President, Chief Information Officer (Centre Daily Times)
Invitrogen Corporation (NASDAQ:IVGN), a provider of essential life science technologies for research, production and diagnostics, today announced the appointment of Joe Beery as head of Invitrogen's Global Information Technology, effective September 8, 2008.

Interdisciplinary Volume On Biological Rhythms Serves As Both Primer And In-depth Resource, New Book (Medical News Today)
A variety of organisms-from bacteria and fungi to plants and animals - have biological rhythms, where the timing and duration of fundamental biological processes is naturally adjusted to allow them to adapt and survive, even under fluctuating environmental conditions.

Rosetta Genomics Identifies Potential microRNA Biomarkers In Blood Serum (BioresearchOnline)
Rosetta Genomics, Ltd., a leader in the development of microRNA-based diagnostic and therapeutic products, announced that the results of a study conducted by its scientists describing the identification of microRNA biomarkers in blood serum, have been published online in the peer-reviewed journal PLOS One

TAU Researchers Create New Stem Cell Screening Tool (BioresearchOnline)
Stem cell research is the next great leap in medicine. In the future, new tissue grown in a laboratory could replace a failing heart, or new cells take the place of damaged cells in the brain. Rather than using stem cells from embryonic sources, which opens difficult ethical and complicated scientific issues, scientists have been looking to adult human stem cells, culled from a person's own body

September 5, 2008 (SeedQuest)
Pakistan has established a national-level body to monitor biosafety measures in the areas of biotechnology and trans-border infectious diseases.

Basel, Switzerland September 5, 2008 (SeedQuest)
BASF Plant Science has licensed Genedata Expressionist® across all of their research centers in Europe and North America. Genedata , the leading provider of in-silico solutions for pharmaceutical R&D and related life sciences, today announced a new license agreement with BASF Plant Science in the plant biotechnology industry.

Researchers Pinpoint Genes Linked to Childhood Inflammatory Bowel Disease (Scientific American)
Researchers have identified a pair of genes that increase a child's risk of developing inflammatory bowel disease (IBD) before the age of 19--adding to a growing list of 30 known genetic factors for the malady. Inflammatory bowel disease is a chronic condition that affects an estimated 1.4 million people in the U.S., according to the Centers for Disease Control and Prevention (CDC) . Abnormal ...

Changes in urine could lead to BSE test for live animals (EurekAlert!)
( BioMed Central ) Researchers have demonstrated that protein levels in urine samples can indicate both the presence and progress of Bovine Spongiform Encephalopathy disease in cattle. Publishing their findings in BioMed Central's open access journal Proteome Science, the scientists hope that their discovery might lead to the development of a urine-based test that could prevent the precautionary ...

Broad foundation donates $400 million to biomedical research institute (Los Angeles Times)
The Massachusetts facility, a joint enterprise of Harvard and MIT, had already received $200 million from philanthropists Eli and Edythe Broad. Los Angeles philanthropists Eli and Edythe Broad announced Thursday that they are donating $400 million, their biggest gift ever, to a Massachusetts biomedical research institute that is a joint enterprise of Harvard University and the Massachusetts ...

Eurofins, Operon in Legal Tussle over Investment in Genomics Venture (GenomeWeb News)
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Princeton Biologist Snags $2.5M Avant-Garde Award for HIV/AIDS Proteomics Studies (GenomeWeb News)
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Scientists ID 2 New Genes for Bowel Disease in Kids (HealthDay via Yahoo! News)
FRIDAY, Sept. 5 (HealthDay News) -- Variations of two new genes appear to increase the risk of developing inflammatory bowel disease in childhood, researchers say.

Scientists ID 2 New Genes for Bowel Disease in Kids (Health Scout)
Findings could lead to tailored treatments for IBD, study suggests.

Pathogen test developed by K-State researchers could be used to detect diseases used by bioterrorists (High Plains Journal)
Dangerous disease often spreads faster than it takes to diagnose it in the lab. To remedy that, researchers at Kansas State University have developed a test to bring that time from days down to hours.

25 Years Of Conventional Evaluation Of Data Analysis Proves Worthless In Practice (Medical News Today)
So-called 'intelligent' computer-based methods for classifying patient samples, for example, have been evaluated with the help of two methods that have completely dominated research for 25 years. Now Swedish researchers at Uppsala University are revealing that this methodology is worthless when it comes to practical problems. The article is published in the journal Pattern Recognition Letters.

Discovery of Potential New Targets In Brain Tumors Following Massive Cancer Gene Search (Medical News Today)
An array of broken, missing, and overactive genes -- some implicated for the first time -- have been identified in a genetic survey of glioblastoma, the most common and deadly form of adult brain cancer, report scientists from Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard, together with their collaborating investigators at 18 institutions and organizations.

Rosetta Genomics Identifies Potential MicroRNA Biomarkers In Blood Serum (Medical News Today)
Rosetta Genomics, Ltd. (NASDQ: ROSG), a leader in the development of microRNA-based diagnostic and therapeutic products, announced that the results of a study conducted by its scientists describing the identification of microRNA biomarkers in blood serum, have been published online in the peer-reviewed journal PLOS One.

Identification Of Structure Of Key Epigenetics Component (Medical News Today)
Scientists from the Structural Genomics Consortium (SGC) have determined the 3D structure of a key protein component involved in enabling "epigenetic code" to be copied accurately from cell to cell.

Business people (Asheville Citizen-Times)
Have some good news to share about yourself or a colleague? Send your announcements to [email protected] with “Business People” in the subject line. We will run submissions as soon as possible and in the order in which they were received.

Finalists for Core Lab chief coming to town (The Salisbury Post)
By Emily Ford [email protected] KANNAPOLIS — Three finalists vying to run the Core Laboratory at the N.C. Research Campus will spend several day ...

A Bioinformatic System Takes Adult Stem Cell Research To A New Level (Medical News Today)
Stem cell research is the next great leap in medicine. In the future, new tissue grown in a laboratory could replace a failing heart, or new cells take the place of damaged cells in the brain. Rather than using stem cells from embryonic sources, which opens difficult ethical and complicated scientific issues, scientists have been looking to adult human stem cells, culled from a person's own body.

Tiny Ancestral Remnant Lends Developmental Edge To Humans (Medical News Today)
Subtle genetic changes that confer an evolutionary advantage upon a species, such as the dexterity characteristic of the human hand, while difficult to detect and even harder to reproduce in a model system, have nevertheless generated keen interest amongst evolutionary biologists. In findings published online in the September 5 edition of the journal Science, researchers from the U.S.

How plants fine tune their natural chemical defenses (EurekAlert!)
Even closely related plants produce their own natural chemical cocktails, each set uniquely adapted to the individual plant's specific habitat. Comparing antifungals produced by tobacco and henbane, researchers at the Salk Institute for Biological Studies discovered that only a few mutations in a key enzyme are enough to shift the whole output to an entirely new product mixture.

How Plants Fine-tune Their Natural Chemical Defenses (Newswise)
Even closely related plants produce their own natural chemical cocktails, each set uniquely adapted to the individual plant's specific habitat. Comparing anti-fungals produced by tobacco and henbane, researchers at the Salk Institute for Biological Studies discovered that only a few mutations in a key enzyme are enough to shift the whole output to an entirely new product mixture.

How plants fine tune their natural chemical defenses (PhysOrg)
Even closely related plants produce their own natural chemical cocktails, each set uniquely adapted to the individual plant's specific habitat. Comparing anti-fungals produced by tobacco and henbane, researchers at the Salk Institute for Biological Studies discovered that only a few mutations in a key enzyme are enough to shift the whole output to an entirely new product mixture. Making fewer ...

How Plants Fine Tune Their Natural Chemical Defenses (Science Daily)
Even closely related plants produce their own natural chemical cocktails, each set uniquely adapted to the individual plant's specific habitat. Comparing antifungals produced by tobacco and henbane, researchers have discovered that only a few mutations in a key enzyme are enough to shift the whole output to an entirely new product mixture.

Senator Obama's Priorities - WashingtonWatch.com (PR Newswire via Yahoo! News)
Of the three federal legislators in the presidential race, Senator Barack Obama (D-IL) is the most prolific legislator as far as bills introduced, but the least successful at getting them passed. None of the 59 bills he has introduced in the current Congress have become law.

Genes Guide Drug Therapy (University of Melbourne University News)
Macedonia-born Slavé Petrovski grew up in St Albans fascinated with science.

BIOTECHCORP ON TRACK TO HAVE 112 BIONEXUS-STATUS FIRMS BY YEAR-END (Bernama via Yahoo! Malaysia News)
KUALA LUMPUR, Sept 8 (Bernama) -- Malaysian Biotechnology Corporation Sdn Bhd (BiotechCorp), the agency tasked with boosting development of biotechnology industry in Malaysia, is on track to have 112 new BioNexus-status companies by year-end, says chief executive Datuk Iskandar Mizal Mahmood.

At Yale, discovering a tiny gene's role in big diseases (BG News)
Nearly 15 years ago, scientists completed one of the largest international projects in research history, tremendous in its scope and importance. They determined the sequence of the nearly 30,000 genes in the human genome. Although the Human Genome Project introduced the concept of 'completeness' to human biology for the first time, it was just the first step toward the eventual goal of using ...

Epigenomics Reports Positive Interim Results in Prostate Cancer Clinical Study (n-tv.de)
Berlin, Germany and Seattle, WA, USA, September 8, 2008 - Epigenomics AG (Frankfurt, Prime Standard: ECX), a cancer molecular diagnostics company developing tests based on DNA methylation, today reported positive interim results from an ongoing prostate cancer trial.

Epigenomics Reports Positive Interim Results in Prostate Cancer Clinical Study (GlobeNewswire via Yahoo! Finance)
BERLIN, and SEATTLE, Sept. 8, 2008 -- Epigenomics AG , a cancer molecular diagnostics company developing tests based on DNA methylation, today reported positive interim results from an ongoing prostate cancer trial.

DJ HUGIN NEWS/Epigenomics Reports Positive Interim Results in Prostate Cancer Clinical Study (Financial.de)
- Clinical study of over 500 patient samples well on track for completion in Q4 2008 - Interim analysis representing approximately half of the cases demonstrates statistical significance for primary endpoint of prostate cancer prognosis (probability of recurrence) - PITX2 biomarker classifies patients into groups at high and low risk for relapse following surgery Berlin, Germany and Seattle, WA, ...

CombiMatrix to Hold Conference Call to Discuss Recent Findings Utilizing Its HemeScan Test for Chronic Lymphocytic ... (GlobeNewswire via Yahoo! Finance)
MUKILTEO, Wash., Sept. 8, 2008 -- CombiMatrix Corporation will hold a conference call to discuss recent findings demonstrating the value of its HemeScan test for Leukemia patients.

Academic Leaders Join Advisory Board Of Assay Depot, The World's First Drug Discovery Outsourcing Marketplace (PharmaceuticalOnline)
Assay Depot announced today that leading researchers from Harvard, Stanford, the University of California, San Francisco (UCSF) and the University of Texas had joined its Advisory Board. Assay Depot is the world's first full-service outsourcing marketplace for pharmaceutical research services.

2009 Award Recipients Named By Biophysical Society (Medical News Today)
The Biophysical Society is pleased to announce the recipients of its 2009 Society awards. The eight recipients will receive their awards at the Society's 53rd Annual Meeting on Monday, March 2, 2009 at the Boston Convention and Exhibitions Center in Massachusetts.


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