Bioinformatics News Apr 2008: bioinformatics, genomics, proteomics, microarray, etc.

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Colombian scientists synthesise potential malaria vaccine
[BOGOTÁ] A Colombian research group has chemically synthesised an early-stage malaria vaccine candidate in the laboratory. (Mon, 07 Apr 2008 16:29:53 GMT)

Children's Hospital Contributes Genetic Data to Enhance Autism Research Worldwide
The Children's Hospital of Philadelphia has contributed a large genotype dataset to the Autism Genetic Resource Exchange (AGRE), a scientific program of the organization Autism Speaks, dedicated to advancing genetic research in autism. This large genetic dataset will now be broadly accessible to autism researchers worldwide. (Mon, 07 Apr 2008 16:30:03 GMT)

Nobel Prize Winner Smithies To Discuss His Career in Talk at UNC
Posted: Today at 2:04 p.m. Chapel Hill, N.C. — Nobel Prize winner Oliver Smithies will share experiences from his life in a public presentation on April 9 at UNC-Chapel Hill. (Mon, 07 Apr 2008 21:54:55 GMT)

New blood test gives early diagnosis of neurodegenerative diseases
A new blood test that can give an early diagnosis of neurodegenerative disease and distinguish between Parkinson's and Alzheimer's disease could be launched this summer, reports Marina Murphy in SCI's Chemistry & Industry magazine. (Mon, 07 Apr 2008 22:38:00 GMT)

Health Briefs (4/9)
The Comprehensive Cancer Center at St. Joseph's Hospital and Medical Center is offering genetic risk assessments to Valley residents who have cancer or a family history of cancer. The initial consultation is free and a physician referral is not required. (Tue, 08 Apr 2008 00:10:01 GMT)

Faster DNA Sequencing
New techniques could finally make a $1,000 genome possible. (Tue, 08 Apr 2008 04:21:31 GMT)

Newly Identified Gene May Prompt Pancreas Cells To Form
Before a pancreas is a pancreas, it's part of the endoderm, one of three layers of cells in a developing embryo that eventually form its organs. Researchers have now uncovered key genetic signals involved in how the pancreas begins forming, a finding they say might lead to regenerative therapies for patients with certain forms of diabetes whose pancreases no longer function. ... (Tue, 08 Apr 2008 05:23:39 GMT)

Plants Grow Spindly When Reaching For Sunlight: Now Researchers Understand How
Those spindly plants that desperately try to reach for a break in the canopy formed by larger plants all suffer from the same affliction: Shade avoidance syndrome or SAS. Now, the molecular details of SAS have been brought to light. (Tue, 08 Apr 2008 05:24:29 GMT)

Children's Hospital Contributes Genotype Data To Enhance Autism Research Worldwide
The Children's Hospital of Philadelphia has contributed a large genotype dataset to the Autism Genetic Resource Exchange (AGRE), a scientific program of the organization Autism Speaks, dedicated to advancing genetic research in autism. This large genetic dataset will now be broadly accessible to autism researchers worldwide. (Tue, 08 Apr 2008 08:18:27 GMT)

$2,500 DNA kit can spot disease, company says
Even though experts say its not ready for prime time, a company that claims it can predict your risk of developing a slew of fatal ailments is trying persuade New Yorkers to plunk down $2,500 to see into the future. (Tue, 08 Apr 2008 08:22:40 GMT)

Grant funding to aid IU myeloma research
Biochemists and molecular biologists at Indiana University have received a $750,000 grant to continue their work on multiple myeloma, a type of cancer that affects about 15,000 new patients each year. (Tue, 08 Apr 2008 08:46:59 GMT)

Reflecting On The Social Implications Of Human Genetics Research - Past, Present, And Future - New Book
In 1911, the influential geneticist Charles Davenport published Heredity in Relation to Eugenics, advancing his ideas of how genetics would improve society in the 20th century. It became a college textbook and a foundation for the widespread eugenics movement in the United States. (Tue, 08 Apr 2008 09:18:17 GMT)

Illumina to Announce First Quarter 2008 Financial Results on Tuesday, April 22, 2008
SAN DIEGO----Illumina, Inc. today announced that it will issue results for first quarter 2008 following the close of market on Tuesday, April 22, 2008. (Tue, 08 Apr 2008 10:00:00 GMT)

Navigenics Proposes Standards for Personal Genomics Services, Coupled With Prospective Outcomes Studies, to Safeguard ...
Navigenics, a personalized genetic health services company, today announced that it will develop a set of industry standards for consumer genomic testing services, and that it will seek broad, multi-stakeholder input and endorsement of these or similar criteria. (Tue, 08 Apr 2008 10:04:00 GMT)

Early Diagnosis Of Neurodegenerative Disease On The Horizon
A new blood test that can give an early diagnosis of neurodegenerative disease and distinguish between Parkinson's and Alzheimer's disease could be launched this summer, reports Marina Murphy in SCI's Chemistry & Industry magazine. (Tue, 08 Apr 2008 10:20:58 GMT)

How To Get Ahead With Pharmacogenomics Highlights How Companies Must Adopt Technologies That Will Enable Them To ...
DUBLIN, Ireland----Research and Markets has announced the addition of new Decision Resources report "How to Get Ahead with Pharmacogenomics" to their offering. (Tue, 08 Apr 2008 10:38:00 GMT)

CombiMatrix Launches BAC HD Scan: Diagnostic for Over 125 Genetic Disorders Including Autism Spectrum Disorder
MUKILTEO, Wash., April 8, 2008 -- CombiMatrix Corporation announced today that its subsidiary, Combimatrix Molecular Diagnostics, Inc. , has completed the clinical validation of and has launched the BAC HD Scan test, its highest density Constitutional Array Genetic Test to date. (Tue, 08 Apr 2008 12:00:00 GMT)

Insight Into The Genetic And Molecular Mechanisms Underpinning Acute Myeloid Leukemia
Leukaemia - cancer of blood or bone marrow - is caused by mutations that allow defective blood cells to accumulate and displace healthy blood. To devise effective therapies it is crucial to know which mutations cause leukaemia and which cell type gives rise to leukaemic cells. (Tue, 08 Apr 2008 12:17:28 GMT)

QuantRx Announces Exclusive Manufacturing and Distribution Agreement for New Presumptive Field Narcotics Testing ...
DOYLESTOWN, Pa.----QuantRx Biomedical Corporation, , a broad-based diagnostics company focused on the development and commercialization of innovative diagnostic products based on its patented technology platforms for the worldwide healthcare industry, today announced that it has concluded the development of the Fieldtests ID product line for identifying drugs-of-abuse residue. (Tue, 08 Apr 2008 12:23:00 GMT)

How a protein mutation causes leukaemia
Washington, April 8 : An international team of researchers has gained fresh insight into how the mutation in a protein called C/EBPa causes leukaemia, cancer of blood or bone marrow. (Tue, 08 Apr 2008 13:12:44 GMT)

Rosetta cancer test heads for approval
The test is designed to differentiate between two types of the most common form of lung cancer. (Tue, 08 Apr 2008 13:24:54 GMT)

Researchers seek blood samples from Sacramento-area West Nile victims
Genetic researchers are reaching out to people who have tested positive for West Nile virus, hoping to get blood samples to study what role genes might play in determining who is hit hardest by the disease. (Tue, 08 Apr 2008 13:40:27 GMT)

Dr. Douglas Amorese Joins NuGEN as VP, Research and Development
SAN CARLOS, Calif.----NuGEN Technologies, Inc., a privately held company that develops and commercializes nucleic acid amplification and labeling systems announced today that it has hired Dr. (Tue, 08 Apr 2008 13:45:00 GMT)

Protein data bank archives 50,000th molecule structure
The Protein Data Bank (PDB) based at Rutgers, The State University of New Jersey, and the University of California-San Diego (UCSD) this month reached a significant milestone in its 37-year history. The 50,000th molecule structure was released into its archive, joining other structures vital to pharmacology, bioinformatics and education. (Tue, 08 Apr 2008 18:01:42 GMT)

Power3 Medical's Chief Executive Officer Steven Rash Contributes To IVD Technology
HOUSTON----Power3 Medical Products, Inc.'s CEO, Steven Rash has contributed an article to the April 2008 issue of IVD Technology magazine. Power3 Medical is a leading proteomics company specializing in the development and commercialization of diagnostic tests for the early detection of breast cancer and neurodegenerative diseases. (Tue, 08 Apr 2008 18:25:00 GMT)

Genesis Genomics goes to market with at-home skin test
Local biotechnology firm Genesis Genomics has launched a new product it hopes will change the face of the cosmoceutical marketplace. (Tue, 08 Apr 2008 20:00:42 GMT)

Enter Navigenics, Where Personal Genomics Gets More Medical
Personal genomics company Navigenics has launched with a plan to move your genome from your cells onto your doctor's clipboard. (Tue, 08 Apr 2008 20:25:12 GMT)

Scientists find a fingerprint of evolution across the human genome
The Human Genome Project revealed that only a small fraction of the 3 billion “letter” DNA code actually instructs cells to manufacture proteins, the workhorses of most life processes. This has raised the question of what the remaining part of the human genome does. How much of the rest performs other biological functions, and how much is merely residue of prior genetic events? (Tue, 08 Apr 2008 21:31:32 GMT)

Hepatitis B virus triggers cell 'suicide' in patients with chronic infection
Scientists from UCL (University College London) have identified a key difference between people who can fight the Hepatitis B virus (HBV) off successfully and those who fail to do so - that a group of cells important in controlling the disease are triggered to ‘commit suicide` in patients who are chronically infected. This discovery provides an important new focus for developing therapies or ... (Tue, 08 Apr 2008 21:31:52 GMT)

RED(TM) Personal Gel Imager Now Available from Alpha Innotech
SAN LEANDRO, Calif.----Alpha Innotech , a leading provider of innovative bioimaging solutions for the life science research market, announced today that it has begun shipment of RED™, its newest gel imaging system. (Tue, 08 Apr 2008 21:42:00 GMT)

RED(TM) Personal Gel Imager Now Available from Alpha Innotech
Alpha Innotech (17243;OTCBB:APNO), a leading provider of innovative bioimaging solutions for the life science (Tue, 08 Apr 2008 22:03:14 GMT)

Rosetta submits first cancer diagnostic tool for approval
Rosetta Genomics and Columbia University Medical Center announced last week that they have submitted the first cancer diagnostic test based on Rosetta Genomics proprietary microRNA technology for approval to the New York State Department of Health clinic. (Tue, 08 Apr 2008 23:34:08 GMT)

At home on a crab, with new evolutionary neighbors
The members of Drosophilidae, a family consisting of about 3000 species, are often referred to as fruit flies although most of the members feed on microbes. As microbes can be found growing on a wide range of substrates, fruit flies can accordingly also be found in a multitude of habitats. (Wed, 09 Apr 2008 00:16:51 GMT)

War on tera: Intel picks C for parallel computing
Intel has been showing off a programming model which it claims will help C and C++ developers take advantage of a parallel computing without the need for any code changes. (Wed, 09 Apr 2008 01:15:44 GMT)

At Home On A Crab, With New Evolutionary Neighbors
Scientists at the Max Planck Institute for Chemical Ecology, Germany, have rediscovered Drosophila endobranchia, a fly living in the mouth of land crabs. The findings are published in PLoS ONE on April 9. The members of Drosophilidae, a family consisting of about 3000 species, are often referred to as fruit flies although most of the members feed on microbes. (Wed, 09 Apr 2008 01:16:47 GMT)

A Novel Approach To Protein Variation In Synapses
Most brain functions, such as memory, require a sophisticated network of molecular interactions. However, experimental methods can only analyze a limited number of these interactions at a time. Now, researchers have pioneered a novel approach, which enables them to analyze hundreds of network molecules simultaneously. They were able to compare the relative amount and, importantly, the ... (Wed, 09 Apr 2008 02:07:10 GMT)

Scientists Find A Fingerprint Of Evolution Across The Human Genome
The Human Genome Project revealed that only a small fraction of the 3 billion "letter" DNA code actually instructs cells to manufacture proteins, the workhorses of most life processes. This has raised the question of what the remaining part of the human genome does. How much of the rest performs other biological functions, and how much is merely residue of prior genetic events? ... (Wed, 09 Apr 2008 02:10:51 GMT)

New mouse model grants insight into the genetic and molecular mechanisms underpinning acute myeloid leukemia
Leukaemia - cancer of blood or bone marrow is caused by mutations that allow defective blood cells to accumulate and displace healthy blood. (Wed, 09 Apr 2008 03:23:00 GMT)

Blood test in the pipeline for early Parkinson's and Alzheimer's
A company in the U.S. says it has a blood test in the pipeline which is able to detect the early signs of Parkinson's and Alzheimer's disease. (Wed, 09 Apr 2008 05:07:50 GMT)

Eck gives $20 million to disease center
Notre Dame alumnus Frank Eck has given the University a $20 million gift to support the Center for Global Health and Infectious Diseases (CGHID), which will be renamed the Eck Family Center for Global Health and Infectious Diseases. (Wed, 09 Apr 2008 06:12:34 GMT)

Genetic researchers seek Sacramento-area West Nile victims
Genetic researchers are reaching out to people nationwide who have tested positive for West Nile virus, hoping to get blood samples to study the role of genes in determining who is hardest hit by the disease. (Wed, 09 Apr 2008 07:17:19 GMT)

Business briefs
SonoSite, which marks its 10th anniversary as a public company this week, said its first-quarter revenue grew by 22 percent compared with the same period last year. (Wed, 09 Apr 2008 07:26:49 GMT)

Intel gives C++ a parallel life
The company's Ct programming model may help C and C++ developers take advantage of a parallel computing without changing any code (Wed, 09 Apr 2008 09:25:18 GMT)

Majority Of Studies Of High-Fat Diets In Mice Inaccurately Portrayed
Studies in mice provide the foundation for much of the belief that high-fat diets are detrimental to human health. However, the majority of studies on the health effects of high-fat diets in mice published in five respected scientific journals in 2007 were not accurately portrayed, a survey by researchers at UC Davis has found. (Wed, 09 Apr 2008 10:19:58 GMT)

Research findings could lead to new treatments for leukaemia
A global research collaboration has made a profound breakthrough in the understanding of the rise of leukaemic cells in the body, challenging accepted scientific thinking and opening a path to a whole range of potential new treatments. (Wed, 09 Apr 2008 11:13:40 GMT)

Invitrogen Teams with MitoSciences to Improve Mitochondrial Disease Research
CARLSBAD, Calif. & EUGENE, Ore.----Invitrogen Corporation , a provider of essential life science technologies for research, production and diagnostics, announced today the company will become the exclusive North American distributor of all MitoSciences products, including antibodies and assays used for researching mitochondrial proteins and diseases. (Wed, 09 Apr 2008 12:00:00 GMT)

Power3 Medical NuroPro(TM) Test Featured In Local, National, and International News Outlets
HOUSTON, Tex.----Power3 Medical Products, Inc. , a leading proteomics company specializing in the development and commercialization of diagnostic tests for the early detection of breast cancer and neurodegenerative diseases, was recently spotlighted in several prominent local, national, and international news outlets. (Wed, 09 Apr 2008 14:09:00 GMT)

Signature Genomic Laboratories Introduces Detection Rates Table
SPOKANE, Wash.----Signature Genomic Laboratories has introduced its updated Detection Rates Table on the company's website. The Detection Rates Table lists, for each of the over 150 genetic disorders tested by Signature's current microarrays, the SignatureChip Whole GenomeTM and SignatureChip Oligo SolutionTM , the likelihood that a chromosome abnormality can be detected by microarray analysis ... (Wed, 09 Apr 2008 14:15:00 GMT)

Agilent Technologies Expands miRNA Microarray Catalog with New Human, Mouse and Rat Assays
SANTA CLARA, Calif.----Agilent Technologies Inc. today introduced three new microRNA microarray designs: Human miRNA Microarray v2.0, Mouse miRNA Microarray v1.0 and Rat miRNA Microarray v1.0. (Wed, 09 Apr 2008 15:00:00 GMT)

New Genomics Software to Determine Ancestry
Computer scientists at Stanford University have developed genomics analysis software that they say appears to be "far more adept than prior methods at unraveling the ancestry of individuals." Known as... (Wed, 09 Apr 2008 15:04:31 GMT)

Hepatitis B Virus Triggers Cell 'Suicide' In Patients With Chronic Infection
Scientists have identified a key difference between people who can fight the Hepatitis B virus (HBV) off successfully and those who fail to do so -- that a group of cells important in controlling the disease are triggered to "commit suicide" in patients who are chronically infected. This discovery provides an important new focus for developing therapies or vaccines that boost the body's ability ... (Wed, 09 Apr 2008 15:08:20 GMT)

Protein Data Bank Archives 50,000th Molecule Structure
The Protein Data Bank (PDB) based at Rutgers, The State University of New Jersey, and the University of California-San Diego (UCSD) this month reached a significant milestone in its 37-year history. The 50,000th molecule structure was released into its archive, joining other structures vital to pharmacology, bioinformatics and education. (Wed, 09 Apr 2008 15:17:07 GMT)

Alexandria, Egypt April 9, 2008
Scientists working on barley genome sequencing are aiming to complete it by 2012. Prof Andreas Graner, Acting Director of the Leibniz Institute of Plant Genetics and Crop Plant Research in Germany, said that the International Barley Sequencing Consortium (IBSC) consisting of eight member laboratories in Australia, Japan, Finland, Germany, United Kingdom and the United States is currently working ... (Wed, 09 Apr 2008 15:19:15 GMT)

New Jobs Follow New Tenant to North Carolina Research Campus
KANNAPOLIS, N.C.----The North Carolina Research Campus announced today at a news conference that PPD, Inc. , a global contract research organization, is opening an office at the campus, which may bring 200 to 300 new jobs. (Wed, 09 Apr 2008 15:24:00 GMT)

Pakistani farming 'suffering results of low investment'
Pakistan is struggling to reverse the effects of low investment in agricultural research in the 1990s, according to experts. (Wed, 09 Apr 2008 15:44:42 GMT)

Hepatitis B virus triggers cell 'suicide' in chronically infected patients
Washington, Apr 9 : Researches at the University College London have shed light on why some people can fight the Hepatitis B virus (HBV) off successfully while some can't, by finding that a group of cells important in controlling the disease are triggered to 'commit suicide' in patients who are chronically infected. (Wed, 09 Apr 2008 15:47:08 GMT)

Deaton Engineering joins Georgetown commercialization center
Georgetown's Texas Life-sciences Commercialization Center has gained a fourth company, Georgetown-based Deaton Engineering. Deaton is a full-service product engineering firm that works with medical devices, biotechnology and pharmaceutical industries. (Wed, 09 Apr 2008 16:34:33 GMT)

PJA Named 2008 Agency of the Year by Advertising Age's BtoB Magazine
Following a year of dramatic increase in revenue, several new account wins, an expansion of its services and the development of innovative marketing programs for clients, BtoB Magazine has named PJA Advertising+Marketing as Agency of the Year, according to Mike O'Toole, executive vice president and Partner of the agency. (Wed, 09 Apr 2008 17:15:00 GMT)

Protein Data Bank Archives 50,000th Molecule Structure
Worldwide Research Archive doubles in size since 2004. (Wed, 09 Apr 2008 17:27:57 GMT)

Hepatitis B Virus Triggers Cell 'Suicide' In Patients With Chronic Infection
Scientists from UCL (University College London) have identified a key difference between people who can fight the Hepatitis B virus (HBV) off successfully and those who fail to do so - that a group of cells important in controlling the disease are triggered to 'commit suicide' in patients who are chronically infected. (Wed, 09 Apr 2008 18:01:57 GMT)

In Storing 1?s and 0?s, the Question Is $
Digital data degrades over time, and it is unclear how best to preserve it or how much it will cost to do so. (Wed, 09 Apr 2008 19:00:30 GMT)

Molecule Delivery Method Improves Stem Cell Differentiation
New research shows that delivering molecules within aggregates of embryonic stem cells via biodegradable microspheres enhances the efficiency and purity of differentiation. (Wed, 09 Apr 2008 19:27:57 GMT)

Method to deliver molecules within embryonic stem cells improves differentiation
Embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. However, the inability of stem cells to efficiently develop into the desired specific cell type - such as muscle, skin, blood vessels, bone or neurons - now limits the potential clinical utility of this therapy. (Wed, 09 Apr 2008 20:16:53 GMT)

Gene Mutations for Rare Heart Disease Also Found in Kids
WEDNESDAY, April 9 (HealthDay News) -- The same 10 gene mutations responsible for cardiac hypertrophy (thickening of the heart muscle) in adults are also associated with many cases of this rare but life-threatening condition in children, says a U.S. study. (Wed, 09 Apr 2008 21:02:32 GMT)

Genetic test offers clues about cardiac hypertrophy in children
Boston, Mass. (April 9, 2008) – A mechanic uses diagnostic tests to determine why your engine is making strange sounds before lifting a wrench to fix the problem. (Wed, 09 Apr 2008 21:13:40 GMT)

Gene Mutations for Rare Heart Disease Also Found in Kids
Copyright © 2008 ScoutNews LLC. All rights reserved. (Wed, 09 Apr 2008 22:07:10 GMT)

Hepatitis B virus triggers cell 'suicide' in patients with chronic infection
Scientists from UCL (University College London) have identified a key difference between people who can fight the Hepatitis B virus (HBV) off successfully and those who fail to do so - that a group of cells important in controlling the disease are triggered to 'commit suicide' in patients who are chronically infected. (Wed, 09 Apr 2008 23:38:20 GMT)

Invitrogen Teams with MitoSciences to Improve Mitochondrial Disease Research
Invitrogen Corporation (NASDAQ:IVGN), a provider of essential life science technologies for research, production and diagnostics, announced today the company will become the exclusive North American distributor of all MitoSciences products, including antibodies and assays used for researching mitochondrial proteins and diseases. MitoSciences currently has the world's largest collection of ... (Wed, 09 Apr 2008 23:43:22 GMT)

Signature Genomic Laboratories Introduces Detection Rates Table
Signature Genomic Laboratories has introduced its updated Detection Rates Table on the company's website. The Detection Rates Table lists, for each of the over 150 genetic disorders tested by Signature's current microarrays, the SignatureChip Whole Genome(TM) (SignatureChipWG(TM)) and SignatureChip Oligo Solution(TM) (SignatureChipOS(TM)), the likelihood that a chromosome abnormality can be ... (Wed, 09 Apr 2008 23:49:55 GMT)

University of Delaware
Composed of short lengths of ribonucleic acids (RNAs), on the order of about 20 nucleotides long, these novel molecules, called natural antisense microRNAs (nat-miRNAs), target the genes sitting directly across from them on the opposite strand of DNA in a rice cell. (Thu, 10 Apr 2008 00:18:55 GMT)

Agilent Technologies Expands miRNA Microarray Catalog with New Human, Mouse and Rat Assays
Agilent Technologies Inc. (NYSE:A) today introduced three new microRNA microarray designs: Human miRNA Microarray v2.0, Mouse miRNA Microarray v1.0 and Rat miRNA Microarray v1.0. All are based on the Sanger Institute's miRBase 10.1, updated in December 2007. (Thu, 10 Apr 2008 00:34:09 GMT)

An Unexpected Way To Cause Leukemia
Researchers have now used genetic engineering to introduce a mutation found in human leukemia patients into mice. In Cancer Cell they report that the mutation causes leukemia by triggering innate genetic programs that allow white blood cells to proliferate uncontrollably. The findings have implications for the way leukemia should be treated. (Thu, 10 Apr 2008 01:08:30 GMT)

Art and science meet on the stage
Who knew that DNA could be a fashion accessory? Even modern dancers, who shrink from anything that carries a whiff of yesterday, have embraced the swanky appeal of deoxyribonucleic acid, the molecules at the heart of today's most happening controversies over genetic engineering. (Thu, 10 Apr 2008 04:45:28 GMT)

$700 million set for upstate revival
The $121.7 billion 2008-09 state budget approved Wednesday in Albany includes a $700 million Upstate Revitalization Fund. (Thu, 10 Apr 2008 07:15:21 GMT)

Takeda to pay $8.8 billion for cancer drugmaker Millennium
Japan’s Takeda Pharmaceutical says Thursday it’s going to pay $8.8 billion to buy Millennium Pharmaceuticals, a U.S. cancer-drug producer. (Thu, 10 Apr 2008 07:33:21 GMT)

New Anti-MMP Antibodies Introduced by AnaSpec AnaSpec Inc. Posted on: 09 Apr 08
Continuing in its commitment to developing new MMP solutions, AnaSpec has introduced its newest MMP antibodies – anti-MMP-8 (hinge), anti-MMP-9 (hinge), anti-MMP-11 (hinge), anti-MMP-13 (IN) and anti-MMP-28 (IN) antibodies. (Thu, 10 Apr 2008 08:50:27 GMT)

10 April 2008
Dr. Christopher P. Austin, Director of the NIH Chemical Genomics Center will give the Keynote Presentation at GTCbio’s 3rd Assay Development & Screening Technologies Conference, June 5-6, 2008 in San Francisco, CA. Dr. Austin will present on “Novel Paradigms to Enable Druggability of Genomic and Orphan Disease Targets.” (Thu, 10 Apr 2008 08:50:36 GMT)

Celera Grants License to Merck & Co., Inc. for Cancer Targets
ALAMEDA, Calif.----Celera , an Applera Corporation business, today announced a two year exclusive license agreement with Merck & Co., Inc. providing Merck with access to up to ten cancer targets for the development of RNA interference- based therapeutics. (Thu, 10 Apr 2008 11:00:00 GMT)

Celera Grants License to Merck & Co., Inc. for Cancer Targets
Celera (NYSE:CRA), an Applera Corporation business, today announced a two year exclusive license agreement with Merck & Co., Inc. providing Merck with access to up to ten cancer targets for the development of RNA interference-(RNAi) based therapeutics. These therapeutic targets are over-expressed on the surface of several different tumor cell types and were identified using Celera's proteomics ... (Thu, 10 Apr 2008 11:10:07 GMT)

Japan's Takeda Will Pay $9B for Millennium
The largest overseas acquisition by a Japanese drug maker comes at a 53% premium to Millennium's Wednesday close. (Thu, 10 Apr 2008 11:12:41 GMT)

Method To Deliver Molecules Within Embryonic Stem Cells Improves Differentiation
Embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. However, the inability of stem cells to efficiently develop into the desired specific cell type - such as muscle, skin, blood vessels, bone or neurons - now limits the potential clinical utility of this therapy. (Thu, 10 Apr 2008 11:18:28 GMT)

Adnavance Technologies Inc. Appoints BioSite Co-Founder Kenneth Buechler, Ph.D., to its Board of Directors
VANCOUVER, British Columbia & SAN DIEGO----Adnavance Technologies Inc., a developer of direct detection molecular diagnostic tests for medical applications, announced today that it has appointed Kenneth Buechler, Ph.D., to its Board of Directors. (Thu, 10 Apr 2008 12:00:00 GMT)

CLC bio develops Digital Gene Expression software for developing the potato plant into a super-crop
CLC bio, several prominent Danish research institutions, and three crop-enhancing companies have joined forces in a project which aims to develop potatoes into a high-efficient, low-maintenance and multipurpose crop, which cannot only be used for animal and human food, but also for energy and chemical production, like biofuel and starch. The project will make extensive use of Next Generation ... (Thu, 10 Apr 2008 12:45:38 GMT)

Takeda Pharmaceutical of Japan to buy Millennium Pharmaceuticals for $8.8 billion
Takeda said Thursday that it would buy the U.S. company in a friendly cash offer of $25 per share to increase its cancer drug business. (Thu, 10 Apr 2008 12:55:18 GMT)

Innovative Drug Discovery Strategies are Critical to the Growth of Pharmaceutical R&D Productivity
DUBLIN, Ireland----Research and Markets has announced the addition of new Decision Resources report: Navigating the Drug Discovery Landscape: A Strategic Overview of Pharmaceutical R&D to their offering. (Thu, 10 Apr 2008 13:00:00 GMT)

Biomarkers may reduce need for biopsies
BOSTON, MA April 10, 2008 – Data presented at this week’s 28th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT) suggest the potential of a significant impact of using biomarkers to reduce the need for biopsies and personalize transplant patient care. (Thu, 10 Apr 2008 13:58:08 GMT)

At New Canaan Library: Ovarian cancer seminar April 17
“Prove to me I don’t have ovarian cancer.” That’s what one specialist advises all women experiencing the disease’s nonspecific symptoms to demand of their doctors, and of themselves. (Thu, 10 Apr 2008 13:59:20 GMT)

Heart And Lung Transplant Patients May No Longer Need Biopsies And Could Receive Personalized Care From Biomarkers
New data suggest the potential of a significant impact of using biomarkers to reduce the need for biopsies and personalize transplant patient care. Non-invasive testing using gene-based blood or urine could offer transplant patients personalized care and medication and may replace the need for costly, invasive biopsy procedures that can be risky for patients. ... (Thu, 10 Apr 2008 15:07:30 GMT)

Takeda Pays $8.8 Billion for Biotechnology Firm
The acquisition of Millennium Pharmaceuticals, one of the earliest American genomics companies, by Japan?s largest drug company spurred a rise in biotechnology stocks. (Thu, 10 Apr 2008 17:33:09 GMT)

These Stocks Beat Gas Stocks
You may be surprised by the real leaders and laggards. (Thu, 10 Apr 2008 18:26:02 GMT)

Gene Mutations for Rare Heart Disease Also Found in Kids
Title: Gene Mutations for Rare Heart Disease Also Found in Kids Category: Health News Created: 4/10/2008 2:00:00 AM Last Editorial Review: 4/10/2008 (Thu, 10 Apr 2008 19:24:08 GMT)

Medical Prognosis Institute Selects Insightful Corporation for Predictive Analytics and Reporting
SEATTLE----Insightful Corporation , a leading provider of predictive analytics and reporting solutions, announced today that Medical Prognosis Institute , a provider of leading-edge technology based on DNA microarrays, has selected S-PLUS® 8 Enterprise Server, Insightful's software platform for statistical data analysis and predictive analytics. (Thu, 10 Apr 2008 20:00:00 GMT)

Stoneville, Mississippi April 10, 2008
A multi-state project to reveal genetic markers for some of the Mid-South’s best rice breeding lines in history is underway with the goal to produce a genetic map of about 470 of the most successful rice varieties. (Thu, 10 Apr 2008 20:47:19 GMT)

Scientists develop strategy to rapidly describe outbreak strains with next-generation DNA sequencing
Friday, April 11, 2008 – In the event of an outbreak or a bioterrorist attack, rapid identification of the genetic changes responsible for virulence or drug resistance is essential to mounting an effective response. (Thu, 10 Apr 2008 21:13:49 GMT)

Molecule delivery method improves stem cell differentiation
Embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. (Fri, 11 Apr 2008 01:18:50 GMT)

Takeda Pays $8.8 Billion for Biotechnology Firm
The acquisition of Millennium Pharmaceuticals, one of the earliest American genomics companies, by Japan’s largest drug company spurred a rise in biotechnology stocks. (Fri, 11 Apr 2008 02:40:34 GMT)

Japanese Drug Company Bids for U.S. Biotech Firm
Japan?s Takeda Pharmaceutical has agreed to pay $8.8 billion in cash for Millennium Pharmaceuticals, one of the earliest American genomics companies. (Fri, 11 Apr 2008 02:48:25 GMT)

Mass. biotech is sold for $8.8b
Millennium Pharmaceuticals Inc. , one of Massachusetts' best-known biotechnology companies, has been sold to Japanese drug maker Takeda Pharmaceutical Co. for $8.8 billion, making it the biggest deal in the history of the state's biotech industry. (Fri, 11 Apr 2008 07:37:08 GMT)

Business news in brief
STATE NEWS Feds bill SoCal slaughterhouse $67 million in biggest beef recall The federal government said Thursday it has billed a California slaughterhouse more than $67 million for expenses associated with the largest beef recall in U. (Fri, 11 Apr 2008 09:18:01 GMT)

Illumina Introduces Three New Research Products to Study Genetic Variations Linked to Cancer Development
SAN DIEGO----Illumina, Inc. today announced that it is making available three new product solutions for cancer research, which include expansion of Illumina's proprietary DASL® Assay to whole-genome profiling, and the launch of DASL focused expression and methylation profiling on Illumina's VeraCode® technology. (Fri, 11 Apr 2008 10:00:00 GMT)

New Anti-MMP Antibodies Introduced by AnaSpec
AnaSpec has introduced its newest MMP antibodies. [PR.com - April 11, 2008] (Fri, 11 Apr 2008 10:09:13 GMT)

Altira Continues Its Leadership in Renewable Energy Investing With Funding for Evolutionary Genomics to Improve ...
Altira Group LLC -- the pioneer and leader in venture capital and private equity funding for energy technology companies -- announced today an investment in Evolutionary Genomics , of Louisville, Colorado. (Fri, 11 Apr 2008 12:00:00 GMT)

Need For Biopsies May Be Reduced By Biomarkers
Data presented at this week's 28th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT) suggest the potential of a significant impact of using biomarkers to reduce the need for biopsies and personalize transplant patient care. (Fri, 11 Apr 2008 12:13:34 GMT)

Worldwide Research Archive Doubles In Size Since 2004
The Protein Data Bank this month reached a significant milestone in its 37-year history as the 50,000th molecule structure was released into its archive, joining other structures vital to pharmacology, bioinformatics, and education. (Fri, 11 Apr 2008 12:15:39 GMT)

Rosetta Genomics to Present Multiple Posters at the Annual American Association of Cancer Research (AACR) Conference
Rosetta Genomics Ltd. , a leader in the development of microRNA-based diagnostics and therapeutics, announced today it will present multiple posters at the upcoming annual AACR conference in San Diego. (Fri, 11 Apr 2008 12:30:00 GMT)

Bioterrorism: Outbreak Strains Can Be Quickly Analyzed With Next-generation DNA Sequencing
Following an outbreak or a bioterrorist attack, standard DNA sequencing and analysis of a pathogen genome for rapid identification of genetic changes or manipulations is time-intensive and likely impractical during an emergency. Researchers have now developed a comparative genomics strategy to drastically reduce the time needed to accurately identify unique genetic properties of a potential ... (Fri, 11 Apr 2008 13:08:19 GMT)

Max Perutz And The Secret Of Life
Max Perutz, a pioneer in the field of protein crystallography and a Nobel laureate, was one of the first to study the molecular structures of proteins. His life story, wonderfully told by Georgina Ferry, was recently published by Cold Spring Harbor Laboratory Press."Max Perutz was not 'just' a scientist," wrote Dr. Richard E. (Fri, 11 Apr 2008 13:14:41 GMT)

Protein Data Bank Archives 50,000th Molecule Structure
The Protein Data Bank has reached a significant milestone in its 37-year history. The 50,000th molecule structure was released into its archive, joining other structures vital to pharmacology, bioinformatics and education. (Fri, 11 Apr 2008 14:09:24 GMT)

Experts In Systems Biology, Molecular Pharmacology And Bioengineering Convene In Barcelona, Invited By IRB Barcelona ...
Although the pharmaceutical industry has dedicated enormous research efforts over the last 50 years to identify new targets and develop new active ingredients, these efforts have met with limited success. One of the main reasons for the failure of many molecules is because the studies have focused, almost exclusively, on the relation between the target protein and the drug. (Fri, 11 Apr 2008 14:15:56 GMT)

AnaSpec Introduces HiLytePlus™ Labeled Secondary Antibodies & Streptavidin
AnaSpec introduces a new collection of secondary antibodies and streptavidin labeled with the new HiLytePlus™ series of fluorescent dyes. [PR.com - November 17, 2007] (Fri, 11 Apr 2008 14:48:36 GMT)

AnaSpec Celebrates the Holidays with Its Customers
AnaSpec will be adding a one pound box of See’s Candy into every order placed from now through the end of the year. [PR.com - November 29, 2007] (Fri, 11 Apr 2008 14:48:58 GMT)

AnaSpec Introduces New Collection of Bcl Peptides
AnaSpec introduced a collection of peptides related to the family of proteins called Bcl-2 (B-cell lymphoma 2) for use in cancer research or cell cycle research. [PR.com - December 06, 2007] (Fri, 11 Apr 2008 14:49:26 GMT)

AnaSpec Releases New Antibodies Brochure
With a collection that has been rapidly expanded in the last few years, AnaSpec has organized its growing selection of antibodies into its newest antibodies brochure. The brochure showcases: • Primary antibodies • HRP, AP and biotin conjugated secondary antibodies • Patented HiLyte™ and HiLytePlus™ labeled secondary antibodies • Cell lysates • Custom polyclonal & monoclonal [PR.com - December ... (Fri, 11 Apr 2008 14:50:07 GMT)

AnaSpec Introduces New Selection of Dye-Labeled Beta-Amyloid Peptides
AnaSpec introduces a new line of labeled amyloid peptides. [PR.com - December 16, 2007] (Fri, 11 Apr 2008 14:50:37 GMT)

AnaSpec Announces a Broad Selection of T-Cell Epitopes
AnaSpec has announced the availability of a wide selection of T-Cell Epitopes, available both individually and pooled. [PR.com - January 23, 2008] (Fri, 11 Apr 2008 14:52:07 GMT)

AnaSpec Introduces 5 New Peptide Synthesis Reagents
AnaSpec added five (5) new peptide synthesis reagents to its combinatorial chemistry collection. [PR.com - February 24, 2008] (Fri, 11 Apr 2008 14:55:39 GMT)

IBM to Host Life Sciences Virtual Conference and Expo
IBM will host a virtual conference and expo focusing on innovations in drug discovery and development on April 16 and 17, 2008. Far more than a webinar, the Life Sciences Virtual Conference and Expo will provide a fully interactive event that incorporates on-line learning, live chat, immersive exhibit booths and sessions, vendor presentations and more. (Fri, 11 Apr 2008 16:00:00 GMT)

Books: The DNA Dilemma --- Grappling With Bad News From Genetic Testing
Genetic testing is ushering in a new era in human health, raising the possibility of preventing disease and identifying people who are most likely to benefit from new drugs. (Fri, 11 Apr 2008 17:30:26 GMT)

Japanese Drug Company Bids for U.S. Biotech Firm
Japan’s Takeda Pharmaceutical has agreed to pay $8.8 billion in cash for Millennium Pharmaceuticals, one of the earliest American genomics companies. (Fri, 11 Apr 2008 17:41:03 GMT)

Medical Prognosis Institute Selects Insightful Corporation for Predictive Analytics and Reporting
Insightful Corporation (NASDAQ:IFUL), a leading provider of predictive analytics and reporting solutions, announced today that Medical Prognosis Institute (http://medical-prognosis.com) a provider of leading-edge technology based on DNA microarrays, has selected S-PLUS(R) 8 Enterprise Server, Insightful's software platform for statistical data analysis and predictive analytics. Medical ... (Fri, 11 Apr 2008 19:01:25 GMT)

SeedQuest - Central information website for the global seed industry
The majority of cultivated rice can be grouped into two major subspecies: indica and japonica. Recent studies showed that the two rice subspecies evolved from two independent domestication events of the Asian cultivated rice. (Fri, 11 Apr 2008 20:02:19 GMT)

New Microarray Technique Reveals Stem Cell Specific MicroRNA Patterns
GenomeWeb Daily News You are not logged in. Existing subscribers login here . New to GenomeWeb Daily News? Register quickly here for your free subscription. (Fri, 11 Apr 2008 20:21:03 GMT)

Biofuel Genomics Firm Gains Investment from Altira
GenomeWeb Daily News You are not logged in. Existing subscribers login here . New to GenomeWeb Daily News? Register quickly here for your free subscription. (Fri, 11 Apr 2008 20:21:13 GMT)

Illumina Introduces Three New Research Products to Study Genetic Variations Linked to Cancer Development
Illumina, Inc. (NASDAQ:ILMN) today announced that it is making available three new product solutions for cancer research, which include expansion of Illumina's proprietary DASL(R) Assay to whole-genome profiling, and the launch of DASL focused expression and methylation profiling on Illumina's VeraCode(R) technology. These new solutions allow researchers to leverage synergies across Illumina ... (Fri, 11 Apr 2008 20:31:16 GMT)

Avesthagen inks pact with Affymetrix for genetic study of Parsi community
Avesthagen has entered into partnership agreement with the US-based Affymetrix Inc. to speed up the genetic study of the Parsee community in India. (Sat, 12 Apr 2008 02:39:11 GMT)

SPRINGDALE : Geneticist finds variety improves research
SPRINGDALE — Researchers have learned over the years that expanding clinical trials to subjects from both sexes, multiple minority groups, and adults and children has improved treatments, a scientist told health workers and educators Friday. (Arkansas Democrat-Gazette Northwest Edition) (Sat, 12 Apr 2008 12:23:27 GMT)

Arizona Tech Council aims for sense of stability and vigor
Local technology experts believe recent changes are reinvigorating the 500-member organization. (Sun, 13 Apr 2008 00:02:12 GMT)

From High Street, Yale profs take on Wall Street
Yale professors prove that “entrepreneurial academic” is not an oxymoron. (Sun, 13 Apr 2008 04:36:32 GMT)

Laird Day offers UWSP students leadership training
On April 21, more than 400 high school sophomores and juniors will visit the University of Wisconsin-Stevens Point for Laird Youth Leadership Day, sponsored by UWSP and the Laird Youth Leadership Foundation. (Sun, 13 Apr 2008 08:55:31 GMT)

Genetic Test Offers Clues About Cardiac Hypertrophy In Children
Some children with unexplained cardiac hypertrophy -- a thickening of the heart muscle -- harbor mutations in the same 10 genes responsible for the condition in many adults. Regardless of the age at which symptoms appear, cardiac hypertrophy can share common genetic roots. (Sun, 13 Apr 2008 16:22:39 GMT)

Biomarkers may reduce the need for biopsies and personalize transplant patient care
Data presented at the 28th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT) suggest the potential of a significant impact of using biomarkers to reduce the need for biopsies and personalize transplant patient care. (Sun, 13 Apr 2008 22:49:33 GMT)

New strategy rapidly describes outbreak strains with next-generation DNA sequencing
In the event of an outbreak or a bioterrorist attack, rapid identification of the genetic changes responsible for virulence or drug resistance is essential to mounting an effective response. (Sun, 13 Apr 2008 23:34:45 GMT)

New Gene Discovery Suggests Which Patients CTI's Brostallicin May Benefit
SAN DIEGO , April 14 /PRNewswire-FirstCall/ -- Systems Medicine LLC (SM), a wholly-owned subsidiary of Cell Therapeutics, Inc. (CTI) (Nasdaq and MTAX: CTIC ), presented data from a preclinical study identifying the genetic markers in patients more likely to respond to treatment with the experimental drug, brostallicin, at the 2008 American Association for Cancer Research (AACR) annual meeting. (Mon, 14 Apr 2008 06:25:44 GMT)

Your genetic rundown on a chip
The last two years have seen an exponential increase in the rate of gene discovery, thanks in large part to the advancements in so-called genotyping chip technology. These small glass or silicon platforms have made quick and easy work of simultaneously analyzing hundreds of thousands of genetic variations that exist in the human genome. (Mon, 14 Apr 2008 07:21:40 GMT)

Gene-environment interaction in yeast gene expression
The nature vs. nurture debate is familiar to most people, and modern conclusions usually predict a balance between the two. A new paper published this week in the open-access journal PLoS Biology shows that there is a similar balance between the genes we inherit nature and the environment nurture in determining thousands of traits in yeast. (Mon, 14 Apr 2008 09:42:22 GMT)

Illumina Launches the iScan(TM) System
SAN DIEGO----Illumina, Inc. today launched the iScan System, a next-generation scanner that provides researchers conducting genotyping and gene expression studies with significantly greater throughput, enhanced automation, and improved ease of use. (Mon, 14 Apr 2008 10:00:00 GMT)

Illumina Launches the iScan(TM) System
Illumina, Inc. (NASDAQ:ILMN) today launched the iScan System, a next-generation scanner that provides researchers conducting genotyping and gene expression studies with significantly greater throughput, enhanced automation, and improved ease of use. When used with the recently launched Infinium(R) High-Density (HD) Human1M-Duo and Human610-Quad Genotyping BeadChips, and Illumina's laboratory ... (Mon, 14 Apr 2008 10:14:35 GMT)

SeqWright Expands Next Generation Lineup with the Addition of 454's GS FLX(TM) System
SeqWright Inc., a leading Genomics CRO, has added 454's GS FLX system to increase the breadth of its next generation offerings and to provide genomic researchers with more cost effective genomics solutions. (Mon, 14 Apr 2008 11:15:00 GMT)

Illumina Introduces Three New Research Products To Study Genetic Variations Linked To Cancer Development
Illumina, Inc. (NASDAQ:ILMN) announced that it is making available three new product solutions for cancer research, which include expansion of Illumina's proprietary DASL® Assay to whole-genome profiling, and the launch of DASL focused expression and methylation profiling on Illumina's VeraCode® technology. (Mon, 14 Apr 2008 12:13:45 GMT)

Rosetta Genomics Signs Agreement With West Coast CLIA Certified Lab to Develop and Validate Tests Applying Company's ...
Rosetta Genomics, Ltd. , a leader in the development of microRNA-based diagnostic and therapeutic products, announced today it has signed an agreement with University of California, Irvine School of Medicine , relating to the development and validation of diagnostic tests based on the company's microRNA technology. (Mon, 14 Apr 2008 12:30:00 GMT)

Power3 Medical Products Receives CLIA Compliance Recertification
HOUSTON----Power3 Medical Products, Inc. , a leading proteomics company specializing in the development and commercialization of diagnostic tests for the early detection of breast cancer and neurodegenerative diseases, has received its CLIA compliance recertification following a CLIA regulatory inspection. (Mon, 14 Apr 2008 12:45:00 GMT)

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